Evidence map›Paper›PMID 34515028›Full record

ArticleeLife2021

Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.

Samuel Kariuki, Zoe A Dyson, Cecilia Mbae, Ronald Ngetich, Susan M Kavai, Celestine Wairimu, Stephen Anyona, Naomi Gitau, Robert Sanaya Onsare, Beatrice Ongandi and 5 more

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. ConfrontingInfection and drug resistance · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The dynamics of blaScientific reports · 2024
    Article
  11. Genetic heterogeneity in theMicrobial genomics · 2024
    Article
  12. Article
  13. Article
  14. medRxiv : the preprint server for health sciences · 2024
    Article
  15. Article
  16. Article
  17. Genotypic Diversity amongInternational journal of clinical microbiology · 2024
    Article
  18. Frontiers in cellular and infection microbiology · 2024
    Article
  19. Fecal Shedding, Antimicrobial Resistance andInternational journal of clinical microbiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Samuel Kariuki *Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID 0000-0003-3209-9503
Zoe A Dyson *Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.ORCID 0000-0002-8887-3492
Cecilia MbaeCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Ronald NgetichCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Susan M KavaiCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Celestine WairimuCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Stephen AnyonaCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Naomi GitauCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Robert Sanaya OnsareCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Beatrice OngandiCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Sebastian DucheneDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Mohamed AliDepartment of International Health, John's Hopkins University, Baltimore, United States.
John David ClemensInternational Diarrheal Diseases Research Centre, Dhaka, Bangladesh.
Kathryn E HoltLondon School of Hygiene & Tropical Medicine, London, United Kingdom.
Gordon DouganCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Funding

Integrating geographical and genetic mapping of salmonella disease in an endemicR01AI099525 · NIAID · KENYA MEDICAL RESEARCH INSTITUTE (KEMRI) · PI GUNN, JOHN S, KARIUKI, SAMUEL M · 2013 to 2024
$1.3M
Department of HealthNIAID NIH HHS R01 AI099525Wellcome TrustWellcome Trust 106158/Z/14/Z
6 · The paper itself

Abstract

Background: Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. Methods: In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls) living in an informal settlement, Nairobi, Kenya. Results: 148 Conclusions: The high rate of multidrug-resistant H58 Funding: National Institutes of Health (R01AI099525); Wellcome Trust (106158/Z/14/Z); European Commission (TyphiNET No 845681); National Institute for Health Research (NIHR); Bill and Melinda Gates Foundation (OPP1175797).

Indexed as

Drug Resistance, Multiple, BacterialAdolescentAnti-Bacterial AgentsCarrier StateCase-Control StudiesChildChild, PreschoolFemaleHumansInfantKenyaMalePhylogenySalmonella typhiTyphoid FeverAnti-Bacterial Agentscarriagechildrenepidemiologyglobal healthH58 lineagesinfectious diseaseKenyamicrobiologymultidrug-resistantS. enterica serovar typhityphoid

Identifiers

PMID34515028
PMCPMC8494480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.