ArticleJournal of the American Heart Association2021
Associations Between Cardiorespiratory Fitness, Cardiovascular Risk, and Cognition Are Mediated by Structural Brain Health in Midlife.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of exercise alone and in combination with time-restricted eating on cognitive health in menopausal women.Frontiers in public health · 2025Trial
- Article
- Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70 years old.BMC medicine · 2025Article
- Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.Scientific reports · 2025Article
- The Functional Connectome Mediates Associations Between Fitness and Cognition Across the Adult Lifespan.Human brain mapping · 2025Article
- Association among cardiorespiratory fitness, plasma biomarkers of pathology and astrocyte reactivity, and cognition in autosomal-dominant Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Article
- Advice to people with Parkinson's in my clinic: Get a cardiopulmonary exercise test.Journal of Parkinson's disease · 2025Article
- Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance.Frontiers in psychology · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- Absolute beta power in exercisers and nonexercisers in preparation for the oddball task.Arquivos de neuro-psiquiatria · 2024Article
- Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine.Journal of personalized medicine · 2024Article
- Brain Health and Cognition in Older Adults: Roadmap and Milestones towards the Implementation of Preventive Strategies.Brain sciences · 2024Review
- Exercise and Protection from Age-Related Cognitive Decline.Current topics in behavioral neurosciences · 2024Review
- Neural mechanisms of the relationship between aerobic fitness and working memory in older adults: An fNIRS study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Examining Demographic Factors, Psychosocial Wellbeing and Cardiovascular Health in Subjective Cognitive Decline in the Brain Health Registry Cohort.The journal of prevention of Alzheimer's disease · 2024Article
- The association between cardiovascular health and cognition in adults with Down syndrome.Journal of neurodevelopmental disorders · 2023Article
- Locus coeruleus and dorsal cingulate morphology contributions to slowed processing speed.Neuropsychologia · 2023Article
- Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function?Frontiers in nutrition · 2023Article
- Investigating the application of "Guttmann Cognitest"Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Background Evidence in older adults suggests that higher cardiorespiratory fitness and lower cardiovascular risk are associated with greater cognition. However, given that changes in the brain that lead to cognitive decline begin decades before the onset of symptoms, understanding the mechanisms by which modifiable cardiovascular factors are associated with brain health in midlife is critical and can lead to the development of strategies to promote and maintain brain health as we age. Methods and Results In 501 middle-aged (aged 40-65 years) adult participants of the BBHI (Barcelona Brain Health Initiative), we found differential associations among cardiorespiratory fitness, cardiovascular risk, and cognition and cortical thickness. Higher cardiorespiratory fitness was significantly associated with better visuospatial abilities and frontal loading abstract problem solving (β=3.16,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.