ReviewVeterinary clinical pathology2022
Analysis of the gut microbiome in dogs and cats.
Review in Veterinary clinical pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed.
- Pilot study evaluating tolerability and changes in fecal microbiota associated with novel probiotic administration to dogs with diarrhea.Frontiers in veterinary science · 2025Trial
- Effect of low dose azithromycin on the fecal microbiome and fecal bile acids in healthy dogs.Journal of veterinary internal medicine · 2026Article
- Beyond Immunity: Functional Outcomes of Dietary Yeast and Seaweed β-Glucans in Adult Canine Nutrition.Journal of animal physiology and animal nutrition · 2026Article
- Short-Term Stability of the Fecal Microbiota in WildMicroorganisms · 2026Article
- Gut Microbiome Disruption in Shelter Cats with Feline Panleukopenia: Virome Co-Detection and Enteric Dysbiosis.Biology · 2026Review
- Targeting the Gut-Brain Axis: Pharmacological Modulation of the Microbiome for Neurological and Behavioural Disorders in Companion Animals.Veterinary medicine and science · 2026Review
- An Ecological Framework for Interpreting the Canine Gut Microbiome.Animals : an open access journal from MDPI · 2026Article
- What Does Bacteria Have to Do with Cancer? The Influence of the Body's Microbiota on Cancer in Cats and Dogs.International journal of molecular sciences · 2026Review
- The Effects of DietaryAnimals : an open access journal from MDPI · 2026Article
- The Gut Microbiome and Metabolome of Domestic Cats Were Altered by the Oral Administration of Complex Probiotics.Biology · 2026Article
- Evaluation of the effect of Renaltec in cats with IRIS stage 2 and 3 chronic kidney disease.Journal of feline medicine and surgery · 2026Article
- Longitudinal long-read microbiome profiling in a canine model reveals how age, diet, and birth mode shape gut community dynamics.mSystems · 2026Article
- The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders-From Mechanisms to Precision Therapeutics.Veterinary sciences · 2026Review
- Article
- Impacts of a fresh-frozen dog food on fecal consistency and microbiome in colony dogs.Journal of animal science · 2026Article
- Article
- Anti-Inflammatory and Antioxidant Effects of Quercetin, Luteolin, and Proanthocyanidins in Canine PBMCs Stimulated withAnimals : an open access journal from MDPI · 2025Article
- Effects of Glucose Oxidase andMetabolites · 2025Article
- Microbial membrane vesicles and the intestinal epithelium: a crosstalk in health and disease.Archives of microbiology · 2025Review
- In Vitro Fermentation Characteristics of Dietary Fibers Using Fecal Inoculum from Dogs Consuming a Dried Brewers Yeast Product.Animals : an open access journal from MDPI · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome is an important immune and metabolic organ. Intestinal bacteria produce various metabolites that influence the health of the intestine and other organ systems, including kidney, brain, and heart. Changes in the microbiome in diseased states are termed dysbiosis. The concept of dysbiosis is constantly evolving and includes changes in microbiome diversity and/or structure and functional changes (eg, altered production of bacterial metabolites). Molecular tools are now the standard for microbiome analysis. Sequencing of microbial genes provides information about the bacteria present and their functional potential but lacks standardization and analytical validation of methods and consistency in the reporting of results. This makes it difficult to compare results across studies or for individual clinical patients. The Dysbiosis Index (DI) is a validated quantitative PCR assay for canine fecal samples that measures the abundance of seven important bacterial taxa and summarizes the results as one single number. Reference intervals are established for dogs, and the DI can be used to assess the microbiome in clinical patients over time and in response to therapy (eg, fecal microbiota transplantation). In situ hybridization or immunohistochemistry allows the identification of mucosa-adherent and intracellular bacteria in animals with intestinal disease, especially granulomatous colitis. Future directions include the measurement of bacterial metabolites in feces or serum as markers for the appropriate function of the microbiome. This article summarizes different approaches to the analysis of gut microbiota and how they might be applicable to research studies and clinical practice in dogs and cats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.