Evidence map›Paper›PMID 34514536›Full record

ArticlePediatric cardiology2022

Third Trimester Fetal Heart Rates in Antibody-Mediated Complete Heart Block Predict Need for Neonatal Pacemaker Placement.

Justin Pick, Michael J Silka, Yaniv Bar-Cohen, Allison Hill, Mark Shwayder, John Wood, Jay D Pruetz

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Justin PickDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA.ORCID http://orcid.org/0000-0002-9947-0285
Michael J SilkaDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA.
Yaniv Bar-CohenDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA.
Allison HillDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA.
Mark ShwayderDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA.
John WoodDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA.
Jay D PruetzDivision of Pediatric Cardiology, Children's Hospital of Los Angeles, Keck School of Medicine at University of Southern California, 4650 W Sunset Boulevard, MS #34, Los Angeles, CA, 90027, USA. jpruetz@chla.usc.edu.
University of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital complete heart block (CCHB) affects 1 in 20,000 newborns. This study evaluates fetal and neonatal risk factors predictive of neonatal pacemaker placement in antibody-mediated complete heart block. The Children's Hospital Los Angeles institutional fetal, pacemaker, and medical record databases were queried for confirmed SSA/SSB cases of CCHB between January 2004 and July 2019. Cases excluded were those with a diagnosis beyond the neonatal period, diagnosis of a channelopathy, or if maternal antibody status was unknown. We recorded the gestational age (GA), birth weight (BW), fetal heart rates (FHRs) of the last echocardiogram before delivery, specific neonatal ECG and echocardiogram findings, age at pacemaker placement, and mortality. Of 43 neonates identified with CCHB, 27 had confirmed maternal antibody exposure. Variables associated with neonatal pacemaker implantation were FHRs < 50 bpm (p = 0.005), neonatal heart rates < 52 bpm (p = 0.015), and neonatal left ventricular fractional shortening (FS) percentages < 34% (p = 0.03). On multivariate analysis, FHR remained significant (p = 0.03) and demonstrated an increased risk of neonatal pacemaker placement by an odds ratio of 12.5 (95% CI 1.3-116, p = 0.05). The median GA at which the FHR was obtained was 34 weeks (IQR 26-35 weeks). Neonatal pacemaker placement was highly associated with a FHR < 50 bpm, neonatal HR < 52 bpm, and neonatal FS < 34%. FHRs at 34 weeks GA (IQR 26-35 weeks) correlated well with postnatal heart rates and were predictive of neonatal pacemaker placement.

Indexed as

Atrioventricular BlockPacemaker, ArtificialChildFemaleHeart Rate, FetalHumansInfant, NewbornPregnancyPregnancy Trimester, ThirdPrenatal CareBradycardiaCongenital heart blockFetal cardiologyFetal echocardiographyLupus antibodiesPacemakerPrenatal diagnosisPrenatal ultrasound

Identifiers

PMID34514536
OpenAlexW3200019140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.