Evidence map›Paper›PMID 34514460›Full record

ArticleBiological psychiatry global open science2021

Understanding the Effects of the COVID-19 Pandemic on Youth Psychopathology: Genotype-Environment Interplay.

Sarah L Carroll, Elizabeth A Shewark, Luke W Hyde, Kelly L Klump, S Alexandra Burt

Abstract read
In one paragraph

Article in Biological psychiatry global open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Temporal change in the prevalence and etiology of youth antisocial behavior.Journal of psychopathology and clinical science · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Introduction to Special Issue on COVID-19 and Mental Health.Biological psychiatry global open science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah L CarrollDepartment of Psychology, Michigan State University, East Lansing, Michigan.
Elizabeth A ShewarkDepartment of Psychology, Michigan State University, East Lansing, Michigan.
Luke W HydeDepartment of Psychology, University of Michigan, Ann Arbor, Michigan.
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, Michigan.
S Alexandra BurtDepartment of Psychology, Michigan State University, East Lansing, Michigan.

Funding

Mechanisms underlying resilience to neighborhood disadvantage (Administrative Supplement)UH3MH114249 · NIMH · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA, HYDE, LUKE WILLIAMSON · 2018 to 2022
$3.5M
Neurobiological pathways underlying maladaptive behaviors in youthR01HD093334 · NICHD · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA, HYDE, LUKE WILLIAMSON · 2017 to 2021
$3.2M
Integrating contextual, proximal, and individual risks for child conduct problemsR01HD066040 · NICHD · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA · 2010 to 2014
$2.9M
Gene-environment Interactions in Childhood Conduct ProblemsR01MH081813 · NIMH · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA · 2008 to 2013
$1.6M
Mechanisms underlying resilience to neighborhood disadvantageUG3MH114249 · NIMH · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA, HYDE, LUKE WILLIAMSON · 2017 to 2017
$402k
Neighborhood, Genotype, and DevelopmentF32HD098780 · NICHD · MICHIGAN STATE UNIVERSITY · PI SHEWARK, ELIZABETH · 2019 to 2022
$226k
The role of environmental disadvantage in the etiologic moderation of children's antisocial behaviorF31HD102094 · NICHD · MICHIGAN STATE UNIVERSITY · PI CARROLL, SARAH LYNN · 2020 to 2022
$114k
NICHD NIH HHS F31 HD102094NICHD NIH HHS F32 HD098780NICHD NIH HHS R01 HD066040NICHD NIH HHS R01 HD093334NIMH NIH HHS R01 MH081813NIMH NIH HHS UG3 MH114249NIMH NIH HHS UH3 MH114249
6 · The paper itself

Abstract

backgroundAdversity has consistently been found to predict poor mental health outcomes in youth. Perhaps the most omnipresent form of adversity in the past several decades has been the coronavirus pandemic of 2020, a global health crisis linked to elevated rates of numerous forms of youth psychopathology. The ongoing nature of the pandemic renders it critical to identify the mechanisms underlying its effects on mental health.

methodsThe current study examines pandemic-related disruption across multiple domains (e.g., home life, finances) as an etiologic moderator of several common forms of youth psychopathology. Participants were 637 adolescent twin pairs from the Twin Study of Behavioral and Emotional Development in Children (TBED-C). Mothers reported on disruption experienced by the family, using the Epidemic-Pandemic Impacts Inventory.

resultsA series of biometric genotype-by-environment interaction models revealed that disruption augmented the nonshared environmental contributions to emotional distress and conduct problems but had little effect on the etiology of attention-deficit hyperactivity problems.

conclusionsOur results indicate that identical and fraternal twin similarity in both emotional symptoms and conduct problems decreased with greater disruption, such that children in the same family became less alike, and did so regardless of their degree of genetic resemblance. Put differently, each twin sibling appeared to have their own idiosyncratic experience of pandemic-related disruptions, with downstream consequences for their mental health.

Indexed as

Coronavirus pandemicGenotype-by-environment interplayYouth psychopathology

Identifiers

PMID34514460
PMCPMC8415869

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.