ArticleJournal of Alzheimer's disease reports2021
Alzheimer's Disease Progressively Reduces Visual Functional Network Connectivity.
Article in Journal of Alzheimer's disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Energy-Based Phase-Locking State Analysis in Brain State Identification.Human brain mapping · 2026Article
- The relation between neuroinflammation, amyloid-β load, grey matter loss and brain activity in visual object recognition regions in Alzheimer's Disease.Neuroimage. Reports · 2026Article
- Algebraic Connectivity Reveals Modulated High-Order Functional Networks in Alzheimer's Disease.ArXiv · 2026Article
- Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI.Biomedical engineering and computational biology · 2026Article
- Individualized functional connectome biomarkers predict clinical symptoms after rTMS treatment in Alzheimer's disease.Translational psychiatry · 2025Article
- Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity.Neurology · 2025Article
- Investigating the impact of type 2 diabetes mellitus on brain function in obstructive sleep apnea patients using regional homogeneity and seed-based functional connectivity methods.Frontiers in neuroscience · 2025Article
- Abnormal EEG microstates in Alzheimer's disease: predictors of β-amyloid deposition degree and disease classification.GeroScience · 2024Article
- Altered resting-state functional connectivity and dynamic network properties in cognitive impairment: an independent component and dominant-coactivation pattern analyses study.Frontiers in aging neuroscience · 2024Article
- Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease.Neuroscience bulletin · 2023Article
- Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model.Pharmaceutics · 2023Article
- An atlas of trait associations with resting-state and task-evoked human brain functional organizations in the UK Biobank.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Brain Representation of Animal and Non-Animal Images in Patients with Mild Cognitive Impairment and Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Article
- Endotype Characterization Reveals Mechanistic Differences Across Brain Regions in Sporadic Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Article
- Sensory processing deficits and related cortical pathological changes in Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
- Inherent regional brain activity changes in male obstructive sleep apnea with mild cognitive impairment: A resting-state magnetic resonance study.Frontiers in aging neuroscience · 2022Article
- The Functional Network of the Visual Cortex Is Altered in Migraine.Vision (Basel, Switzerland) · 2021Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPostmortem studies of brains with Alzheimer's disease (AD) not only find amyloid-beta (Aβ) and neurofibrillary tangles (NFT) in the visual cortex, but also reveal temporally sequential changes in AD pathology from higher-order association areas to lower-order areas and then primary visual area (V1) with disease progression.
objectiveThis study investigated the effect of AD severity on visual functional network.
methodsEight severe AD (SAD) patients, 11 mild/moderate AD (MAD), and 26 healthy senior (HS) controls undertook a resting-state fMRI (rs-fMRI) and a task fMRI of viewing face photos. A resting-state visual functional connectivity (FC) network and a face-evoked visual-processing network were identified for each group.
resultsFor the HS, the identified group-mean face-evoked visual-processing network in the ventral pathway started from V1 and ended within the fusiform gyrus. In contrast, the resting-state visual FC network was mainly confined within the visual cortex. AD disrupted these two functional networks in a similar severity dependent manner: the more severe the cognitive impairment, the greater reduction in network connectivity. For the face-evoked visual-processing network, MAD disrupted and reduced activation mainly in the higher-order visual association areas, with SAD further disrupting and reducing activation in the lower-order areas.
conclusionThese findings provide a functional corollary to the canonical view of the temporally sequential advancement of AD pathology through visual cortical areas. The association of the disruption of functional networks, especially the face-evoked visual-processing network, with AD severity suggests a potential predictor or biomarker of AD progression.
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