Evidence map›Paper›PMID 34514206›Full record

ArticleKidney international reports2021

Prescription Practices in Patients With Mild to Moderate CKD in India.

Narayan Prasad, Ashok Kumar Yadav, Monica Kundu, Jasmin Sethi, Ajay Jaryal, Dipankar Sircar, Gopesh K Modi, Kajal Kamboj, Manisha Sahay, Natarajan Gopalakrishnan and 10 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 3 countries.

Narayan PrasadDepartment of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India.
Ashok Kumar YadavDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Monica KunduGeorge Institute for Global Health India, New Delhi, India.
Jasmin SethiDepartment of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ajay JaryalDepartment of Nephrology, Indira Gandhi Medical College, Shimla, India.
Dipankar SircarDepartment of Nephrology Institute of Post Graduate Medical Education and Research, Kolkata, India.
Gopesh K ModiSamarpan Kidney Institute and Research Center, Bhopal, India.
Kajal KambojDepartment of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Manisha SahayDepartment of Nephrology, Osmania Medical College, Osmania General Hospital, Hyderabad, India.
Natarajan GopalakrishnanRajiv Gandhi Government General Hospital, Chennai, India.
Prabhjot KaurDepartment of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sanjay VikrantDepartment of Nephrology, Indira Gandhi Medical College, Shimla, India.
Santosh VarugheseDepartment of Nephrology, Christian Medical College, Vellore, India.
Seema Baid-AgrawalDepartment of Nephrology and Transplant Center, Sahlgrenska University Hospital, University of Gothenburg, Sweden.
Shivendra SinghDepartment of Nephrology, Institute of Medical Science, Banaras Hindu University, Varanasi, India.
Sishir GangDepartment of Nephrology, Muljibhai Patel Urological Hospital, Nadiad, India.
Sreejith ParameswaranDepartment of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Vivek KumarDepartment of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Arpita GhoshGeorge Institute for Global Health India, New Delhi, India.
Vivekanand JhaGeorge Institute for Global Health India, New Delhi, India.
Post Graduate Institute of Medical Education and Research · INGeorge Institute for Global Health · INIndira Gandhi Medical College · INBanaras Hindu University · INChristian Medical College & Hospital · INGovernment General Hospital · INGujarat Kidney Foundation · INInstitute of Post Graduate Medical Education and Research · INJawaharlal Institute of Post Graduate Medical Education and Research · INManipal Academy of Higher Education · INMuljibhai Patel Urological Hospital · INOsmania Medical College · INSahlgrenska University Hospital · SESanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients with chronic kidney disease (CKD) require multiple medications. There is no information on prescription patterns or the use of evidence-based therapies for management of CKD from low-middle-income countries. Using baseline data from the Indian CKD (ICKD) cohort, we describe the drug prescription practices in patients with mild to moderate CKD.

methodsThe ICKD study is a prospective, observational cohort study of mild to moderate kidney disease across 11 centers in India. We analyzed all the prescriptions captured at enrollment in the ICKD study. Drugs were categorized into 11 different groups. We provide descriptive data on prescription details and evaluate the appropriateness of medication use.

resultsComplete prescription data were available in 3966 out of 4056 (97.8%) subjects enrolled in the ICKD database. Most patients had stage 3 CKD, 24.9% had diabetic kidney disease, 87% had hypertension, and 25.5% had moderate to severe proteinuria. Renin-angiotensin-aldosterone system blockers were prescribed in less than half (47.9%) and in 58.8% of patients with proteinuric CKD. Metformin was prescribed in 25.7% of diabetic subjects with CKD. Only 40.4% of patients were taking statins; 31.1% and 2.8% subjects with anemia were receiving iron and erythropoiesis-stimulating agents, respectively.

conclusionThis study highlights the missed opportunities for improving outcomes through appropriate prescriptions of drugs in patients with CKD. There is need for dissemination of evidence-based guidelines and institution of sustainable implementation practices for improving the overall health of patients with CKD.

Indexed as

antihypertensiveschronic kidney diseasesindigenous medicinesprescription pattern

Identifiers

PMID34514206
PMCPMC8418981
OpenAlexW3176071760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.