ReviewKidney international reports2021
Frailty in CKD and Transplantation.
Review in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Effects of exercise training on frailty, cardiorespiratory fitness, and lower limb function in non-dialysis chronic kidney disease: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The prevalence of frailty among older adults with maintenance hemodialysis: a systematic.BMC nephrology · 2025Pooled it
- The prevalence and influencing factors of frailty in patients with chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis.BMC nephrology · 2023Pooled it
- Daily Step Counts in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in medicine · 2022Pooled it
- Development and validation of a nomogram for identifying pre-frailty risk in middle-aged and elderly maintenance hemodialysis patients: a cross-sectional study.BMC nephrology · 2026Article
- The effect of regular physical activity during hemodialysis on levels of FOXO proteins and myostatin concentration.Archives of medical science : AMS · 2026Article
- Preoperative Creatinine-to-Cystatin C Ratio and 1-year Risk of Infection-Related Hospitalization or Death with a Functioning Graft in Older Kidney Transplant Recipients.Clinical interventions in aging · 2026Article
- Prevalence of frailty in hemodialysis patients and its impact on long-term survival in elderly hemodialysis patients.Frontiers in medicine · 2026Article
- Frailty Impact on Kidney Transplantation in Older People.Kidney international reports · 2025Article
- A Qualitative Study Describing the Perspectives on Frailty and Its Management in Individuals with Kidney Failure.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Comprehensive Geriatric Assessment (CGA) and Optimisation Services in Older Kidney Patients: Results from the First UK-Wide Transplant Centre and Renal Unit Survey Study.Journal of clinical medicine · 2025Article
- SGLT2 inhibitors reduce the risk of renal failure in CKD stage 5 patients with Type 2 DM.Scientific reports · 2025Observational
- Kidney replacement therapies in the older person: challenges to decide the best option.Clinical kidney journal · 2025Review
- Article
- Article
- Current status and development trends in CKD with frailty research from 2000 to 2021: a bibliometric analysis.Renal failure · 2024Review
- A Multicenter Home-based Prehabilitation Intervention in Kidney Transplant Candidates.Transplantation direct · 2024Article
- Impact of arteriovenous fistula formation on trajectory of kidney function decline: a target trial emulation.Clinical kidney journal · 2024Article
- Frailty and post-transplant adverse outcomes among kidney transplant recipients A systematic review and meta-analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The population is aging. Although older adults have higher rates of comorbidities and adverse health events, they represent a heterogeneous group with different health trajectories. Frailty, a clinical syndrome of decreased physiological reserve and increased susceptibility to illness and death, has emerged as a potential risk stratification tool in older patients with chronic kidney disease (CKD). Frailty is commonly observed in patients with CKD and associated with numerous adverse outcomes, including falls, decreased quality of life, hospitalizations, and death. Multiple pathologic factors contribute to the development of frailty in patients with CKD, including biological mechanisms of aging and physiological dysregulation. Current interventions to reduce frailty are promising, but additional investigations are needed to determine whether optimizing frailty measures improves renal and overall health outcomes. This review of frailty in CKD examines frailty definitions, the impact of frailty on health outcomes across the CKD spectrum, mechanisms of frailty, and antifrailty interventions (e.g., exercise or senescent cell clearance) tested in CKD patients. In addition, existing knowledge gaps, limitations of current frailty definitions in CKD, and challenges surrounding effective antifrailty strategies in CKD are considered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.