Evidence map›Paper›PMID 34514017›Full record

ArticleOpen forum infectious diseases2021

Increased Capsule Thickness and Hypermotility Are Traits of Carbapenem-Resistant

Nadya Rakovitsky, Jonathan Lellouche, Debby Ben David, Sammy Frenk, Polet Elmalih, Gabriel Weber, Hadas Kon, David Schwartz, Liat Wolfhart, Elizabeth Temkin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Antimicrobial agents and chemotherapy · 2026
    Article
  5. Treating Extensively Drug-ResistantPathogens (Basel, Switzerland) · 2026
    Review
  6. Article
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  8. Article
  9. Review
  10. Phage-encoded depolymerases as a strategy for combating multidrug-resistantFrontiers in cellular and infection microbiology · 2024
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nadya RakovitskyNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Jonathan LelloucheNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Debby Ben DavidNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Sammy FrenkNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Polet ElmalihNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Gabriel WeberThe B. Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Hadas KonNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
David SchwartzNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Liat WolfhartNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Elizabeth TemkinNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Yehuda CarmeliNational Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv, Israel.
Israel Ministry of Health · ILTel Aviv University · ILCarmel Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsHere we describe strains of CRAB that were isolated from fulminant cases in 2 hospitals in Israel. These isolates show a rare hypermucoid (HM) phenotype and were investigated using phenotypic assays, comparative genomics, and an in vivo

resultsThe 3 isolates belonged to the ST3 international clonal type and were closely related to each other, as shown by Fourier-transform infrared spectroscopy and phylogenetic analyses. These isolates possessed thickened capsules and a dense filamentous extracellular polysaccharides matrix as shown by transmission electron microscopy (TEM), and overexpressed the capsule polysaccharide synthesis pathway-related

conclusionsThe HM isolates possessed a unique combination of virulence genes involved in iron metabolism, protein secretion, adherence, and membrane glycosylation. HM strains were more virulent than control strains in 2

Indexed as

capsulecarbapenem-resistant Acinetobacter baumanniiK-locusmucoid phenotypevirulence

Identifiers

PMID34514017
PMCPMC8423469
OpenAlexW3191749477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.