Evidence map›Paper›PMID 34513930›Full record

ArticleFrontiers in molecular biosciences2021

Structural Polymorphism of Chitin and Chitosan in Fungal Cell Walls From Solid-State NMR and Principal Component Analysis.

Liyanage D Fernando, Malitha C Dickwella Widanage, Jackson Penfield, Andrew S Lipton, Nancy Washton, Jean-Paul Latgé, Ping Wang, Liqun Zhang, Tuo Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 105 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Chaotropic Ions Reshape the Cell Wall of the Obligate HalophilebioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Liyanage D FernandoDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, United States.
Malitha C Dickwella WidanageDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, United States.
Jackson PenfieldDepartment of Chemical Engineering, Tennessee Technological University, Cookeville, TN, United States.
Andrew S LiptonEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States.
Nancy WashtonEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States.
Jean-Paul LatgéUnité des Aspergillus, Département de Mycologie, Institut Pasteur, Paris, France.
Ping WangDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Liqun ZhangDepartment of Chemical Engineering, Tennessee Technological University, Cookeville, TN, United States.
Tuo WangDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, United States.
Louisiana State University · USTennessee Technological University · USEnvironmental Molecular Sciences Laboratory · USInstitut Pasteur · FRLouisiana State University Health Sciences Center New Orleans · USPacific Northwest National Laboratory · US

Funding

Using Solid-State NMR Spectroscopy to Elucidate Cell Wall Structural Dynamics Involved in Virulence and Drug Response of Aspergillus fumigatusR21AI149289 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI WANG, PING, WANG, TUO · 2020 to 2021
$414k
NIAID NIH HHS R21 AI149289
6 · The paper itself

Abstract

Chitin is a major carbohydrate component of the fungal cell wall and a promising target for novel antifungal agents. However, it is technically challenging to characterize the structure of this polymer in native cell walls. Here, we recorded and compared

Indexed as

AspergillusCandidacell wallchitinchitosanfungiprincipal component analysissolid-state NMR

Identifiers

PMID34513930
PMCPMC8423923
OpenAlexW3194798628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.