Evidence map›Paper›PMID 34513920›Full record

ArticleFrontiers in molecular biosciences2021

Extracellular and Intracellular Angiotensin II Regulate the Automaticity of Developing Cardiomyocytes

Zenghua Qi, Tao Wang, Xiangmao Chen, Chun Kit Wong, Qianqian Ding, Heinrich Sauer, Zhi-Feng Chen, Cheng Long, Xiaoqiang Yao, Zongwei Cai and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Zenghua QiSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China.
Tao WangState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, SAR China.
Xiangmao ChenSchool of Life Sciences, South China Normal University, Guangzhou, China.
Chun Kit WongSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China.
Qianqian DingSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China.
Heinrich SauerDepartment of Physiology, Justus Liebig University Giessen, Giessen, Germany.
Zhi-Feng ChenInstitute of Environmental Health and Pollution Control, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, China.
Cheng LongSchool of Life Sciences, South China Normal University, Guangzhou, China.
Xiaoqiang YaoSchool of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China.
Zongwei CaiState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, SAR China.
Suk Ying TsangSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR China.
Chinese University of Hong Kong · CNHong Kong Baptist University · HKSouth China Normal University · CNGuangdong University of Technology · CNUniversity of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin II (Ang II) plays an important role in regulating various physiological processes. However, little is known about the existence of intracellular Ang II (iAng II), whether iAng II would regulate the automaticity of early differentiating cardiomyocytes, and the underlying mechanism involved. Here, iAng II was detected by immunocytochemistry and ultra-high performance liquid chromatography combined with electrospray ionization triple quadrupole tandem mass spectrometry in mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs) and neonatal rat ventricular myocytes. Expression of AT

Indexed as

angiotensin IIangiotensin II receptorcalciumdeveloping cardiomyocytesspontaneous action potential

Identifiers

PMID34513920
PMCPMC8425478
OpenAlexW3195506524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.