Evidence map›Paper›PMID 34513879›Full record

ArticleFrontiers in medicine2021

Fluorinated PLGA-PEG-Mannose Nanoparticles for Tumor-Associated Macrophage Detection by Optical Imaging and MRI.

Giorgia Zambito, Siyuan Deng, Joost Haeck, Natasa Gaspar, Uwe Himmelreich, Roberta Censi, Clemens Löwik, Piera Di Martino, Laura Mezzanotte

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Giorgia ZambitoDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Siyuan DengSchool of Pharmacy, University of Camerino, Camerino, Italy.
Joost HaeckApplied Molecular Imaging Facility of Erasmus MC (AMIE) Core Facility, Erasmus Medical Center, Rotterdam, Netherlands.
Natasa GasparDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Uwe HimmelreichBiomedical MR Unit, Molecular Small Animal Imaging Center (MoSAIC), University of Leuven (KU Leuven), Leuven, Belgium.
Roberta CensiSchool of Pharmacy, University of Camerino, Camerino, Italy.
Clemens LöwikDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Piera Di MartinoSchool of Pharmacy, University of Camerino, Camerino, Italy.
Laura MezzanotteDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Erasmus MC · NLUniversità di Camerino · ITErasmus University Rotterdam · NLKU Leuven · BEPercuros (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) promote cancer growth and metastasis, but their role in tumor development needs to be fully understood due to the dynamic changes of tumor microenvironment (TME). Here, we report an approach to visualize TAMs by optical imaging and by Fluorine-19 (

Indexed as

19Fbreast cancercell trackingcontrast agentmagnetic resonance imagingperfluorocarbontumor-associated macrophage

Identifiers

PMID34513879
PMCPMC8429784
OpenAlexW3198788340

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.