Evidence map›Paper›PMID 34513856›Full record

ArticleFrontiers in medicine2021

Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates.

Jennifer M Lang, Leslie R Sedgeman, Lei Cai, Joseph D Layne, Zhen Wang, Calvin Pan, Richard Lee, Ryan E Temel, Aldons J Lusis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jennifer M LangDepartments of Medicine, Microbiology and Human Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
Leslie R SedgemanDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, United States.
Lei CaiCardiovascular Research Center, University of Kentucky, Lexington, KY, United States.
Joseph D LayneCardiovascular Research Center, University of Kentucky, Lexington, KY, United States.
Zhen WangDepartment of Physiology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Calvin PanDepartments of Medicine, Microbiology and Human Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
Richard LeeIonis Pharmaceuticals, Carlsbad, CA, United States.
Ryan E TemelCardiovascular and Metabolic Diseases, Novartis Institutes for Biomedical Research, Cambridge, MA, United States.
Aldons J LusisDepartments of Medicine, Microbiology and Human Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USUniversity of Kentucky · USIonis Pharmaceuticals (United States) · USShandong University · CN

Funding

Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Effects of Anti-miR-33 on Atherosclerosis Regression and RCT in Nonhuman PrimatesR01HL111932 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TEMEL, RYAN EUGENE · 2013 to 2017
$3.6M
Gut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6M
NEPHROLOGY SCIENTIST TRAINING GRANTT32DK007789 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURTZ, IRA · 2000 to 2017
$1.5M
Mechanisms For PPARdelta Agonist-Induced Elevation of HDL in Non-Human PrimatesR00HL088528 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TEMEL, RYAN EUGENE · 2009 to 2011
$743k
Mechanisms For PPARdelta Agonist-Induced Elevation of HDL in Non-Human PrimatesK99HL088528 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TEMEL, RYAN EUGENE · 2007 to 2008
$173k
NHLBI NIH HHS K99 HL088528NHLBI NIH HHS R00 HL088528NHLBI NIH HHS R01 HL111932NHLBI NIH HHS R01 HL144651NIDDK NIH HHS R01 DK117850NIDDK NIH HHS T32 DK007789
6 · The paper itself

Abstract

The gut microbiome influences nutrient processing as well as host physiology. Plasma lipid levels have been associated with the microbiome, although the underlying mechanisms are largely unknown, and the effects of dietary lipids on the gut microbiome in humans are not well-studied. We used a compilation of four studies utilizing non-human primates (

Indexed as

bile acidshigh-fat dietlipidsmicrobiomeprimate

Identifiers

PMID34513856
PMCPMC8426918
OpenAlexW3196763909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.