Evidence map›Paper›PMID 34513848›Full record

ArticleFrontiers in cell and developmental biology2021

Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors

Alborz Karimzadeh, Erika S Varady, Vanessa M Scarfone, Connie Chao, Karin Grathwohl, Pauline U Nguyen, Yasamine Ghorbanian, Irving L Weissman, Thomas Serwold, Matthew A Inlay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alborz KarimzadehSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Erika S VaradySue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Vanessa M ScarfoneSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Connie ChaoSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Karin GrathwohlSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Pauline U NguyenSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Yasamine GhorbanianSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Irving L WeissmanInstitute of Stem Cell Biology and Regenerative Medicine and Ludwig Center, Stanford University, Stanford, CA, United States.
Thomas SerwoldJoslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
Matthew A InlaySue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · USCalifornia Institute for Regenerative Medicine · USJoslin Diabetes Center · US

Funding

Identifying the precursor to hematopoietic stem cells in the mouse embryo and improving its engraftment upon transplantationR21CA224022 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI INLAY, MATTHEW A · 2019 to 2020
$352k
Identifying precursors to hematopoietic stem cells and where they arise in the mouse embryoR56HL133656 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI INLAY, MATTHEW A · 2016 to 2016
$342k
NCI NIH HHS R21 CA224022NHLBI NIH HHS R56 HL133656
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) are defined by their self-renewal, multipotency, and bone marrow (BM) engraftment abilities. How HSCs emerge during embryonic development remains unclear, but are thought to arise from hemogenic endothelium through an intermediate precursor called "pre-HSCs." Pre-HSCs have self-renewal and multipotent activity, but lack BM engraftability. They can be identified functionally by transplantation into neonatal recipients, or by

Indexed as

embryoembryonic hematopoiesisflow cytometryhematopoietic stem cell (HSC)hematopoietic stem cell transplantationneonatal transplantation

Identifiers

PMID34513848
PMCPMC8425522
OpenAlexW3195715322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.