Evidence map›Paper›PMID 34513822›Full record

ArticleFrontiers in cell and developmental biology2021

High-Mobility Group A1 Promotes Cardiac Fibrosis by Upregulating FOXO1 in Fibroblasts.

Qingwen Xie, Qi Yao, Tongtong Hu, Zhulan Cai, Jinhua Zhao, Yuan Yuan, Qing Qing Wu, Qi-Zhu Tang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  10. Article
  11. How Chromatin Stiffens Fibroblasts.Current opinion in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qingwen XieDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Qi YaoDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Tongtong HuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Zhulan CaiDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Jinhua ZhaoDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yuan YuanDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Qing Qing WuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Qi-Zhu TangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Renmin Hospital of Wuhan University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-mobility group A1 (HMGA1) acts as a transcription factor in several cardiovascular diseases. However, the implications of HMGA1 in cardiac fibrosis remain unknown. Here, we investigated the impact of HMGA1 on cardiac fibrosis. A mouse cardiac fibrosis model was constructed

Indexed as

cardiac dysfunctioncardiac fibrosisfibroblastsFOXO1high-mobility group A1

Identifiers

PMID34513822
PMCPMC8427498
OpenAlexW3198201872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.