Evidence map›Paper›PMID 34513724›Full record

ArticleFrontiers in cellular and infection microbiology2021

Fecal Microbiota Transplant Mitigates Adverse Outcomes Seen in Patients Colonized With Multidrug-Resistant Organisms Undergoing Allogeneic Hematopoietic Cell Transplantation.

Andrew J Innes, Benjamin H Mullish, Rohma Ghani, Richard M Szydlo, Jane F Apperley, Eduardo Olavarria, Renuka Palanicawandar, Edward J Kanfer, Dragana Milojkovic, Julie A K McDonald and 6 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05824689 terminatednot on this mapstarted 2022, after this paper: background citation

Exploratory Study of Fluoroquinolone Resistance for Patients Undergoing Autologous Hematopoietic Stem Cell (HSC) Transplantation in the Treatment of Multiple Myeloma

TypeobservationalSponsorHackensack Meridian HealthRan2022 to 2025Enrolled124ConditionsMultiple Myeloma
NCT06355583 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

TypeinterventionalSponsorImperial College LondonRan2024 to 2027Enrolled50ConditionsAcute Lymphoblastic Leukaemia, Acute Leukemia of Ambiguous Lineage, Chronic Myeloid Leukemia, Chronic Myelomonocytic LeukemiaArmsEBX-102, Placebo
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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  8. Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026
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  13. IntestinalBMJ open · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Andrew J InnesCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Benjamin H MullishDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Rohma GhaniDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Richard M SzydloCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Jane F ApperleyCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Eduardo OlavarriaCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Renuka PalanicawandarCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Edward J KanferCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Dragana MilojkovicCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Julie A K McDonaldMedical Research Council (MRC) Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Eimear T BranniganNational Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, United Kingdom.
Mark R ThurszDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Horace R T WilliamsDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Frances J DaviesMedical Research Council (MRC) Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Julian R MarchesiDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Jiří PavlůCentre for Haematology, Imperial College London at Hammersmith Hospital, London, United Kingdom.
Imperial College London · GBHammersmith Hospital · GBMedical Research Council · GBNational Institute for Health Research · GB

Funding

Department of HealthMedical Research Council MR/R000875/1Medical Research Council MR/T005254/1Wellcome Trust
6 · The paper itself

Abstract

The gut microbiome can be adversely affected by chemotherapy and antibiotics prior to hematopoietic cell transplantation (HCT). This affects graft success and increases susceptibility to multidrug-resistant organism (MDRO) colonization and infection. We performed an initial retrospective analysis of our use of fecal microbiota transplantation (FMT) from healthy donors as therapy for MDRO-colonized patients with hematological malignancy. FMT was performed on eight MDRO-colonized patients pre-HCT (FMT-MDRO group), and outcomes compared with 11 MDRO colonized HCT patients from the same period. At 12 months, survival was significantly higher in the FMT-MDRO group (70%

Indexed as

Gastrointestinal MicrobiomeHematopoietic Stem Cell TransplantationDrug Resistance, Multiple, BacterialFecal Microbiota TransplantationHumansRetrospective Studiesantimicrobial resistancefecal microbiota transplantgut microbiotahematological malignanceshematopoietic (Stem) cell transplantation (HCT)multidrug resistant bacteria

Identifiers

PMID34513724
PMCPMC8430254
OpenAlexW3198879253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.