ArticleFrontiers in oncology2021
A Case of Adult Pancreatoblastoma With Novel
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Adult-Onset Pancreatoblastoma.ACG case reports journal · 2025Article
- Adult pancreatoblastoma: Systematic review of the literature and case report of a young adult patient.World journal of gastrointestinal oncology · 2025Article
- Diagnosis, treatment, and prognosis of adult pancreatoblastoma.Cancer medicine · 2024Review
- Blastomas of the digestive system in adults: A review.World journal of gastrointestinal surgery · 2024Review
- Adult pancreatoblastoma with atypical histological morphology combined with familial adenomatous polyposis: a rare case report.Frontiers in oncology · 2024Article
- Review
- MCL1 as putative target in pancreatoblastoma.Virchows Archiv : an international journal of pathology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreatoblastoma is a rare malignant epithelial neoplasm of the pancreas that mainly occurs in children and involves abnormalities in the WNT/β-catenin pathway, such as CASE PRESENTATION: An elderly man, who underwent elective distal pancreatectomy and splenectomy, was referred to our hospital with a mass in the tail of the pancreas. Histologically, the lesion revealed proliferation of clear, basophilic, and cartilaginous tumor cells with lymphatic metastasis. Each of the morphologically distinct tumor components showed different immunohistochemical patterns, indicating heterogeneous differentiation, including epithelial (both acinar and ductal), mesenchymal, and neuroendocrine differentiation. All tumor components showed nuclear expression of β-catenin and cyclin D1. Per next-generation sequencing (NGS), the clear and basophilic tumor cells shared mutations in SUMMARY: In conclusion, the clear and basophilic cells of the tumor were supposedly derived from the same clone and subsequently acquired additional mutations. This is the first report of clonal evolution in pancreatoblastoma.
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Registered trials
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