Evidence map›Paper›PMID 34513688›Full record

ArticleFrontiers in oncology2021

High Variability in Cellular Proliferation, Gene Expression, and Cytokine Production in the Nonneoplastic Colonic Epithelium of Young

Alyssa A Leystra, Kristen N Harvey, Esther Kaunga, Harvey Hensley, Lisa A Vanderveer, Karthik Devarajan, Margie L Clapper

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alyssa A LeystraCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Kristen N HarveyCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Esther KaungaCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Harvey HensleyBiological Imaging Facility, Fox Chase Cancer Center, Philadelphia, PA, United States.
Lisa A VanderveerCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Karthik DevarajanBiostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA, United States.
Margie L ClapperCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Fox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
TRAINING PROGRAM IN CANCER RESEARCHT32CA009035 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CHERNOFF, JONATHAN · 1985 to 2020
$10.5M
NCI NIH HHS P30 CA006927NCI NIH HHS T32 CA009035
6 · The paper itself

Abstract

An urgent need exists to identify efficacious therapeutic preventive interventions for individuals who are at high risk of developing colorectal cancer. To maximize the benefits of preventive intervention, it is vital to identify the time interval during which the initiation of a preventive intervention will lead to an optimal outcome. The goal of the present study was to determine if oncogenic events can be detected in the nonneoplastic colonic mucosa of

Indexed as

cancer preventionchemopreventioncolorectal cancer preventioncytokine signalingimmunopreventiontumor initiation

Identifiers

PMID34513688
PMCPMC8429936
OpenAlexW3196453935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.