Evidence map›Paper›PMID 34513315›Full record

ArticleOncoimmunology2021

Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H Josephs, Heather J Bax, Amy E Gilbert, Tihomir S Dodev, Silvia Mele, Giulia Chiarruttini, Silvia Crescioli and 6 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  2. Engineered Antibodies as Cancer Radiotheranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  3. Article
  4. Antibody Engineering for Nuclear Imaging and Radioimmunotherapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Francis ManSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.ORCID 0000-0002-5076-2180
Alexander KoersSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Panagiotis KaragiannisSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0001-6459-7561
Debra H JosephsSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0002-5610-9123
Heather J BaxSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0003-0432-4160
Amy E GilbertSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.
Tihomir S DodevSchool of Cancer & Pharmaceutical Sciences, Guy's Hospital, King's College London, London, UK.
Silvia MeleSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0003-3709-5739
Giulia ChiarruttiniSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0002-2548-3307
Silvia CrescioliSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0002-1909-5957
Jitesh ChauhanSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.
Julia E BlowerSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Margaret S CooperSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
James SpicerSchool of Cancer & Pharmaceutical Sciences, Guy's Hospital, King's College London, London, UK.ORCID 0000-0003-3732-8491
Sophia N KaragiannisSchool of Basic & Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.ORCID 0000-0002-4100-7810
Philip J BlowerSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.ORCID 0000-0001-6290-1590
Guy's Hospital · GBKing's College London · GBKing's College - North Carolina · US

Funding

Cancer Research UK 16463Cancer Research UK C30122/A11527Cancer Research UK C30122/A15774Medical Research Council MR/L023091/1Wellcome Trust
6 · The paper itself

Abstract

IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in oncology (AllergoOncology). As the pharmacokinetics of IgE antibodies are less well understood, we used molecular imaging in mice to compare the distribution and elimination of IgE and IgG antibodies targeting the human tumor-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4). Anti-CSPG4 IgE and IgG1 antibodies with human Fc domains were radiolabeled with

Indexed as

Antigens, NeoplasmMelanomaAnimalsImmunoglobulin EImmunoglobulin GMiceMice, Inbred NODMolecular ImagingAntigens, NeoplasmImmunoglobulin EImmunoglobulin GallergoimmunologyAllergooncologycancer immunotherapyIgEIgGmolecular imagingnuclear imagingSPECT

Identifiers

PMID34513315
PMCPMC8425638
OpenAlexW3194243546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.