Evidence map›Paper›PMID 34513312›Full record

ArticleMolecular therapy. Nucleic acids2021

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells.

Mark Li, Fan Shao, Qingwen Qian, Wenjie Yu, Zeyuan Zhang, Biyi Chen, Dan Su, Yuwei Guo, An-Vi Phan, Long-Sheng Song and 5 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Chasing the Ghost Proteome in the Dark Matter.Molecular & cellular proteomics : MCP · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Microproteins unveiling new dimensions in cancer.Functional & integrative genomics · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Regulation of insulin secretion by the post-translational modifications.Frontiers in cell and developmental biology · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Mark LiDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Fan ShaoDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Qingwen QianDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Wenjie YuPappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Zeyuan ZhangDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Biyi ChenFraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Dan SuDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Yuwei GuoIowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA 52242.
An-Vi PhanIowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA 52242.
Long-Sheng SongFraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Samuel B StephensFraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Julien SebagFraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Yumi ImaiFraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Ling YangDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Huojun CaoDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
University of Iowa · USFraternal Order of Eagles · US

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Role of Lipid Droplet Proteins in Islet Function in Diabetes and ObesityR01DK090490 · NIDDK · UNIVERSITY OF IOWA · PI IMAI, YUMI · 2011 to 2025
$5.0M
T-tubule remodeling and Ca2+-dependent arrhythmogenesis in cardiomyopathies.R01HL090905 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2008 to 2017
$4.0M
ERK1/2-Integrin Signaling in Desmosome-Dyad CrosstalkR01HL157741 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2021 to 2024
$2.5M
Molecular Determinants of MG53 in Heart Structure and FunctionR01HL157781 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2021 to 2024
$2.2M
Integration of Inflammatory Signaling and the Unfolded Protein Response by Nitrosylation Signaling in ObesityR01DK108835 · NIDDK · UNIVERSITY OF IOWA · PI YANG, LING · 2018 to 2022
$1.9M
BLRD VA I01 BX002334NHLBI NIH HHS R01 HL090905NHLBI NIH HHS R01 HL157741NHLBI NIH HHS R01 HL157781NIDDK NIH HHS P30 DK054759NIDDK NIH HHS R01 DK090490NIDDK NIH HHS R01 DK108835
6 · The paper itself

Abstract

Micropeptides (microproteins) encoded by transcripts previously annotated as long noncoding RNAs (lncRNAs) are emerging as important mediators of fundamental biological processes in health and disease. Here, we applied two computational tools to identify putative micropeptides encoded by lncRNAs that are expressed in the human pancreas. We experimentally verified one such micropeptide encoded by a β cell- and neural cell-enriched lncRNA TCL1 Upstream Neural Differentiation-Associated RNA (

Indexed as

computational biologydiabetesendoplasmic reticulumisletslncRNAmicropeptidessORF

Identifiers

PMID34513312
PMCPMC8416971
OpenAlexW3183781882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.