Evidence map›Paper›PMID 34513251›Full record

ArticleBiomedical optics express2021

In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device.

Christopher G Lui, Wihan Kim, James B Dewey, Frank D Macías-Escrivá, Kumara Ratnayake, John S Oghalai, Brian E Applegate

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  5. Imaging theJournal of biomedical optics · 2025
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christopher G LuiDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.
Wihan KimDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0002-4448-7215
James B DeweyDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.
Frank D Macías-EscriváDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.
Kumara RatnayakeDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.
John S OghalaiDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.
Brian E ApplegateDepartment of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 5708, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0003-2795-5678
University of Southern California · US

Funding

Cochlear mechanics in the mouseR01DC014450 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John S Oghalai · 2015 to 2026
$5.6M
Mechanisms of cochlear synaptopathy after noise or blast traumaR01DC017741 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2020 to 2024
$3.1M
Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomesR01EB027113 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI APPLEGATE, BRIAN E. · 2019 to 2022
$2.6M
Optical coherence tomography for 3D measures of cochlear mechanics in vivoR01DC013774 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2015 to 2019
$2.1M
NIBIB NIH HHS R01 EB027113NIDCD NIH HHS R01 DC013774NIDCD NIH HHS R01 DC014450NIDCD NIH HHS R01 DC017741
6 · The paper itself

Abstract

We describe an optical coherence tomography and vibrometry system designed for portable hand-held usage in the otology clinic on awake patients. The system provides clinically relevant point-of-care morphological imaging with 14-44 µm resolution and functional vibratory measures with sub-nanometer sensitivity. We evaluated various new approaches for extracting functional information including a multi-tone stimulus, a continuous chirp stimulus, and alternating air and bone stimulus. We also explored the vibratory response over an area of the tympanic membrane (TM) and generated TM thickness maps. Our results suggest that the system can provide real-time

Identifiers

PMID34513251
PMCPMC8407818
OpenAlexW3179969008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.