Evidence map›Paper›PMID 34513230›Full record

ArticleBiomedical optics express2021

Characterizing the aggressiveness of prostate cancer using an all-optical needle photoacoustic sensing probe: feasibility study.

Linyu Ni, Javed Siddiqui, Aaron M Udager, Janggun Jo, John T Wei, Matthew S Davenport, Paul L Carson, J Brian Fowlkes, Xueding Wang, Guan Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Linyu NiDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Javed SiddiquiDepartment of Pathology, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Aaron M UdagerMichigan Center for Translational Pathology, Rogel Cancer Center, Department of Pathology, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Janggun JoDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
John T WeiDepartment of Urology, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Matthew S DavenportDepartment of Radiology, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Paul L CarsonDepartment of Radiology, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
J Brian FowlkesDepartment of Radiology, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
Guan XuDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Measuring Molecular and Mechanical Outcomes of Endoscopic Dilation of Fibrotic StricturesR01DK125687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Guan Xu · 2020 to 2026
$3.3M
Real time fine needle assessment of architectural heterogeneity in prostate cancerR37CA222829 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, GUAN · 2019 to 2025
$3.2M
NCI NIH HHS R37 CA222829NEI NIH HHS P30 EY007003NIDDK NIH HHS R01 DK125687
6 · The paper itself

Abstract

In our previous studies, we have developed a prototype interstitial needle sensing probe that can acquire broadband A-line photoacoustic (PA) signals encoding both tissue microarchitecture and histochemical information comparable to that accessible by histology. Paving the road toward clinical translation of this technology, we replaced the piezoelectric hydrophone in the needle PA probe with a fiber optic hydrophone that enabled both broader bandwidth and sufficient signal-to-noise ratio (SNR) for PA signal detection. Such an all-optical design also facilitated disposability and significantly reduced the footprint of the needle PA sensing probe. Experiments were performed on well-controlled phantoms and human prostate tissues. The microarchitectures in each sample were quantitatively evaluated by both the nonlinear spectral slope of the PA signal power spectrum and the generalized gamma (GG) parameter

Identifiers

PMID34513230
PMCPMC8407826
OpenAlexW3175930470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.