ArticleSurgical neurology international2021
Outcome of diffuse axonal injury in moderate and severe traumatic brain injury.
Article in Surgical neurology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Clinical applications of electrical stimulation for peripheral nerve injury: a systematic review.Frontiers in neuroscience · 2023Pooled it
- Surgical timing and mortality in acute traumatic subdural hematoma: is the four-hour threshold confounded by injury severity?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Continuum of Irreversible and Potentially Reversible Traumatic Brain Injury Sequelae: Axonal Injury and Hydrocephalus.Korean journal of neurotrauma · 2026Review
- Myelin sheaths persist for weeks following axon degeneration.Science advances · 2026Article
- Functional recovery of patients with moderate and severe traumatic brain injury after extended and standard early rehabilitation.Frontiers in human neuroscience · 2026Article
- Blast Injuries.Advances and technical standards in neurosurgery · 2026Review
- Contusions bias cortical thickness estimates after traumatic brain injury: A TRACK-TBI study.NeuroImage. Clinical · 2026Article
- Moderate and severe traumatic brain injury: abbreviated injury scale scoring and coding of traumatic axonal injury from early MRI.BMC emergency medicine · 2025Article
- Integrative Diagnostic and Prognostic Paradigms in Diffuse Axonal Injury: Insights from Clinical, Histopathological, Biomolecular, Radiological, and AI-Based Perspectives.International journal of molecular sciences · 2025Review
- Dynamic changes in neuron-specific enolase level to glasgow coma scale score ratio predict long-term neurological function of diffuse axonal injury patients.BMC neurology · 2025Observational
- Study on serum miR-185-5p in assessing the injury severity and prognosis of patients with traumatic brain injury.Journal of medical biochemistry · 2023Article
- Article
- Role of Magnetic Resonance Imaging in Acute Head Injury Patients with Normal Computed Tomography Brain Findings.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiffuse axonal injury (DAI) is a common presentation in neurotrauma. Prognosis is variable but can be dependent on the initial presentation of the patient. In our study, we evaluated the outcome of diffuse axonal injury.
methodsThis study was conducted at a tertiary care center from September 2018 to December 2019 and included 133 adult patients with moderate or severe head injury (GCS ≤ 12) diagnosed to have the DAI on the basis of MRI. At 3 months, the result was assessed using the Extended Glasgow Outcome Scale (GOS-E).
resultsThere were a total of 97 (72.9%) males and 36 (27.1%) females with an average age of 32.4 ± 10 years with a mean GCS of 9 at admission. The most common mode of head trauma was road traffic accidents (RTAs) in 51.9% of patients followed by fall from height in 27.1%. Most patients were admitted with moderate traumatic brain injury (64.7%) and suffered Grade I diffuse axonal injury (41.4%). The average hospital stay was 9 days but majority of patients stayed in hospital for ≤ 11 days. At 3 months, mortality rate was 25.6% and satisfactory outcome observed in 48.1% of patients. The highest mortality was observed in the Grade III DAI.
conclusionWe conclude that the severity of the traumatic head injury and the grade of the DAI impact the outcome. Survivors require long-term hospitalization and rehabilitation to improve their chances of recovery.
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