Evidence map›Paper›PMID 34513096›Full record

ArticleCase reports in endocrinology2021

Prolonged Honeymoon Period in a Thai Patient with Adult-Onset Type 1 Diabetes Mellitus.

Yotsapon Thewjitcharoen, Ekgaluck Wanothayaroj, Haruethai Jaita, Soontaree Nakasatien, Siriwan Butadej, Ishant Khurana, Scott Maxwell, Assam El-Osta, Waralee Chatchomchuan, Sirinate Krittiyawong and 1 more

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06273631 (Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06273631 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes

TypeinterventionalSponsorYang TaoRan2024 to 2027Enrolled80ConditionsType 1 Diabetes, Diet Intervention, Glucose ControlArmsdiverse carbohydrate diet, moderate carbohydrate diet
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Prolonging Partial Remission in Type 1 Diabetes: The Role of Low-Carbohydrate Diet: A Literature Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 5 countries.

Yotsapon ThewjitcharoenDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-2317-4041
Ekgaluck WanothayarojDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Haruethai JaitaDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Soontaree NakasatienDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Siriwan ButadejDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Ishant KhuranaEpigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia.
Scott MaxwellEpigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia.
Assam El-OstaEpigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0001-7968-7375
Waralee ChatchomchuanDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Sirinate KrittiyawongDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Thep HimathongkamDiabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.
Bangkok Hospital · THMonash University · AUChinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe a usual case of adult-onset T1DM with prolonged honeymoon period for more than 5 years.

methodsRepeated mixed meal stimulation tests for a period of 6-12 months together with monitoring pancreatic autoantibodies and laboratory data were followed following the onset of diagnosis.

resultsWe report a 24-year-old Thai patient with T1DM with sustained remission without antidiabetic medication for more than 5 years while maintaining low-carbohydrate intake and regular exercise. Repeated mixed meal stimulation tests for a period of 6-12 months revealed preserved beta-cell functions. Interestingly, repeated pancreatic autoantibodies at 5 years after diagnosis still showed positive anti-GAD, anti-IA2, and anti-ZnT8.

conclusionRestored beta-cell function with complete insulin withdrawal in new-onset T1DM has been reported in very few cases with some common factors as in our patient (low-carbohydrate intake with regular exercise). Delaying autoimmune activity by reducing metabolic load in newly diagnosed T1DM might play a role in maintaining the honeymoon period and could lead to an innovative therapeutic option in new-onset T1DM.

Identifiers

PMID34513096
PMCPMC8429022
OpenAlexW3197857525

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.