Evidence map›Paper›PMID 34513064›Full record

ArticleSovremennye tekhnologii v meditsine2021

Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.

A A Bakibaev, V P Tuguldurova, M V Lyapunova, V V Ivanov, O A Kaidash, E V Udut, M V Bukterov, E E Buyko, A S Kasyanova, V S Malkov

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

A A BakibaevEngineer, Laboratory of Synthesis of High-Energy Compounds, Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch of the Russian Academy of Sciences, 1 Sotsialisticheskaya St., Biysk, 659322, Russia.
V P TuguldurovaEngineer, Laboratory of Synthesis of High-Energy Compounds, Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch of the Russian Academy of Sciences, 1 Sotsialisticheskaya St., Biysk, 659322, Russia.
M V LyapunovaEngineer, Laboratory of Synthesis of High-Energy Compounds, Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch of the Russian Academy of Sciences, 1 Sotsialisticheskaya St., Biysk, 659322, Russia.
V V IvanovAssociate Professor, Head of the Center for Preclinical Research, Central Research Laboratory, Siberian State Medical University, 2 Moskovsky trakt, Tomsk, 634050, Russia.
O A KaidashSenior Researcher, Center for Preclinical Research, Central Research Laboratory, Siberian State Medical University, 2 Moskovsky trakt, Tomsk, 634050, Russia.
E V UdutProfessor of the Russian Academy of Sciences, Head of Central Research Laboratory, Siberian State Medical University, 2 Moskovsky trakt, Tomsk, 634050, Russia.
M V BukterovResearcher, Center for Preclinical Research, Central Research Laboratory, Siberian State Medical University, 2 Moskovsky trakt, Tomsk, 634050, Russia.
E E BuykoPhD Student, Research School of Chemical and Biomedical Technologies, National Research Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk, 634050, Russia, Researcher, Center for Preclinical Research, Central Research Laboratory, Siberian State Medical University, 2 Moskovsky trakt, Tomsk, 634050, Russia.
A S KasyanovaLaboratory Assistant, Laboratory of Organic Synthesis, Research Office, National Research Tomsk State University, 36 Lenin Avenue, Tomsk, 634050, Russia.
V S MalkovHead of the Laboratory of Organic Synthesis, Research Office, National Research Tomsk State University, 36 Lenin Avenue, Tomsk, 634050, Russia.
Siberian State Medical University · RUNational Research Tomsk State University · RUSiberian Branch of the Russian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature. Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia). Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test. Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area. The presence of adhesions was assessed on day 8 after the operation. Commercial membrane Seprafilm (USA) was used as a reference sample. Results: It was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt. % had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1. Flat adhesions were not detected when using Seprafilm. When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten. Conclusion: The obtained films are promising for preventing adhesions as a barrier-type agent. Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.

Indexed as

Carboxymethylcellulose SodiumSodiumAnimalsFemaleHeterocyclic Compounds, 2-RingImidazolesImidazolidinesMiceRatsRats, WistarTissue AdhesionsCarboxymethylcellulose SodiumglycolurilHeterocyclic Compounds, 2-RingImidazolesImidazolidinesSodiumanti-adhesive agentsbarrier filmscarbamide-containing heterocyclic compoundscomposite materialscytotoxicity of film materialsglycoluril

Identifiers

PMID34513064
PMCPMC8353686
OpenAlexW3133629685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.