ArticleAnnals of medicine and surgery (2012)2021
Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report.
Article in Annals of medicine and surgery (2012), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- New-onset psychosis following COVID-19 vaccination: a systematic review.Frontiers in psychiatry · 2024Pooled it
- Cardiac and Neurological Complications Post COVID-19 Vaccination: A Systematic Review of Case Reports and Case Series.Vaccines · 2024Review
- Article
- Acute psychosis induced by mRNA-based COVID-19 vaccine in adolescents: A pediatric case report.Pediatrics and neonatology · 2023Article
- Review
- A review of neurological side effects of COVID-19 vaccination.European journal of medical research · 2023Review
- A review of the potential neurological adverse events of COVID-19 vaccines.Acta neurologica Belgica · 2023Review
- Post-COVID-19 vaccine acute encephalitis in an adult patient: A case report and literature review.Clinical case reports · 2023Article
- Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Review
- Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?Vaccines · 2023Review
- The clinical neurophysiology of COVID-19-direct infection, long-term sequelae and para-immunization responses: A literature review.Clinical neurophysiology practice · 2023Review
- Autoimmune encephalitis after BBIBP-CorV (Sinopharm) COVID-19 vaccination: a case report.BMC neurology · 2022Article
- AI-CoV Study: Autoimmune Encephalitis Associated With COVID-19 and Its Vaccines-A Systematic Review.Journal of clinical neurology (Seoul, Korea) · 2022Article
- A Possible Case of Autoimmune Encephalitis After mRNA COVID-19 Booster Vaccine: A Case Report.Cureus · 2022Article
- Article
- Safety of COVID-19 Vaccines: Spotlight on Neurological Complications.Life (Basel, Switzerland) · 2022Review
- Cytomegalovirus Proctitis Developed after COVID-19 Vaccine: A Case Report and Literature Review.Vaccines · 2022Article
- Article
- Article
- Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report.Vaccines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. CASE PRESENTATION: In this report, we describe a 32-year-old previously healthy man who developed acute confusion, memory disturbances, and auditory hallucination within 24 hours from getting his first dose of the COVID-19 Moderna vaccine.EEG showed features of encephalopathy, CSF investigations were nonspecific, and MRI head did not depict any abnormality. He received five days of ceftriaxone and acyclovir without any benefit. DISCUSSION: Extensive workup for different causes of acute encephalopathy, including autoimmune encephalitis, was negative. Also, Our patient improved dramatically after receiving methylprednisolone, supporting an immune-mediated mechanism behind his acute presentation. Accordingly, we think the COVID-19 vaccine is the only possible cause of our patient presentation, giving the temporal relationship and the absence of other risk factors for encephalopathy.
conclusionthe clinician should be aware of the possible neurological complications of the different COVID-19 vaccines. Further research is needed to clarify the pathophysiology of such complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.