ArticleJournal of clinical and experimental dentistry2021
Cytotoxicity and dentin composition alterations promoted by different chemomechanical caries removal agents: A preliminary
Article in Journal of clinical and experimental dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Effect of Enzymatic-based chemomechanical caries removal agent on proliferation and osteogenic differentiation of dental pulp stem cells.BMC oral health · 2025Article
- Evaluation of the Effectiveness of Different Caries Removal Methods in Primary Teeth With Micro-Computed Tomography and Scanning Electron Microscopy-Energy Dispersive Spectroscopy of X-Ray.Microscopy research and technique · 2025Article
- Bond strength to dentin after chemomechanical caries removal.Journal of clinical and experimental dentistry · 2025Article
- Histological Evaluation of Chemo Mechanical Caries Removal with a Babaco-Based Formulation Gel.Gels (Basel, Switzerland) · 2025Article
- In Vitro Bond Strength of Dentin Treated with Sodium Hypochlorite: Effects of Antioxidant Solutions.Antioxidants (Basel, Switzerland) · 2024Review
- An in-vitro evaluation of residual dentin retained after using novel enzymatic-based chemomechanical caries removal agents.Scientific reports · 2024Article
- Microhardness and characterization of human dental tissue after application of enzymatic chemical agents:Journal of clinical and experimental dentistry · 2024Article
- A Bibliometric Analysis (2010-2020) of the Dental Scientific Literature on Chemo-Mechanical Methods of Caries Removal Using Carisolv and BRIX3000.Medicina (Kaunas, Lithuania) · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of chemomechanical agents for caries removal has been indicated as a non-invasive treatment option; however, their possible deleterious effects on the dental-pulp complex have been insufficiently studied. This study assessed the direct cytotoxicity of two chemomechanical caries removal agents (Brix 3000™ - BX and Papacarie Duo™ - PD) on pulp cells from deciduous teeth, as well as to assess the morphology and chemical compositions of the dentin surface after the application of these materials. MATERIAL AND
methodsThe cells were seeded (50,000 cells/cm²) in a culture medium (DMEM with 10% fetal bovine serum - FBS). After 24 hours, the BX and PD materials were added to 1:20, 1:100, and 1:1000 dilutions. Non-exposed cells were considered as the control group. The viability test (MTT), Trypan Blue assay (TB), and cell morphology (Scanning Electron Microscopy - SEM) were performed after 24 hours of agent application. For the SEM and chemical (energy-dispersive X-ray spectrometry - EDS) dentin evaluation, 0.3-mm-thick dentin discs were obtained and divided into control group (no treatment) and surfaces covered with 37% phosphoric acid, BX, or PD. Data were compared by one-way ANOVA and Tukey's test (
resultsDecreases in cell viability and numbers of viable cells were observed for both materials, at all dilutions, when compared with the control group (
conclusionsBoth materials showed cytotoxicity when in direct contact with the pulp cells from deciduous teeth, and the BX material presented lower cytotoxicity than the PD material. Moreover, both materials did not significantly change the dentin composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.