Evidence map›Paper›PMID 34512728›Full record

ArticleFrontiers in genetics2021

Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing.

Avijit Podder, Anish Raju, Nicholas J Schork

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator.International journal of environmental research and public health · 2023
    Review
  9. Article
  10. Translational control in cell ageing: an update.Biochemical Society transactions · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Avijit PodderDepartment of Quantitative Medicine, The Translational Genomics Research Institute (TGen), Phoenix, AZ, United States.
Anish RajuDepartment of Quantitative Medicine, The Translational Genomics Research Institute (TGen), Phoenix, AZ, United States.
Nicholas J SchorkDepartment of Quantitative Medicine, The Translational Genomics Research Institute (TGen), Phoenix, AZ, United States.
Translational Genomics Research Institute · USCity Of Hope National Medical Center · US

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI FRED H GAGE · 2004 to 2026
$102.6M
Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
Integrative Omics to enhance therapeutics development for healthy agingUH2AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI EVANS, DANIEL SPENCER, MILLER, RICHARD A · 2019 to 2020
$1.4M
NIA NIH HHS U19 AG023122NIA NIH HHS U24 AG051129NIA NIH HHS UH2 AG064706NIA NIH HHS UH3 AG064706
6 · The paper itself

Abstract

Intensive research efforts have been undertaken to slow human aging and therefore potentially delay the onset of age-related diseases. These efforts have generated an enormous amount of high-throughput data covering different levels in the physiologic hierarchy, e.g., genetic, epigenetic, transcriptomic, proteomic, and metabolomic, etc. We gathered 15 independent sources of information about genes potentially involved in human longevity and lifespan (

Indexed as

cross-species orthologsdrug targetshuman agingnutrient sensingpathway enrichmentsprotein-protein interaction network

Identifiers

PMID34512728
PMCPMC8430347
OpenAlexW3197707214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.