Evidence map›Paper›PMID 34512670›Full record

ArticleFrontiers in immunology2021

Follicular Helper T (T

Natarajan Ayithan, Lydia Tang, Susanna K Tan, Diana Chen, Jeffrey J Wallin, Simon P Fletcher, Shyam Kottilil, Bhawna Poonia

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
    Review
  3. Article
  4. Liver Macrophages in the Pathogenesis of Viral Hepatitis.Current issues in molecular biology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. The effect of PD-1/PD-L1 signaling axis on the interaction between CD19Advances in rheumatology (London, England) · 2023
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Natarajan AyithanDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Lydia TangDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Susanna K TanClinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Diana ChenClinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Jeffrey J WallinClinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Simon P FletcherClinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Shyam KottililDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Bhawna PooniaDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Gilead Sciences (United States) · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying signaling pathways that induce B cell response can aid functional cure strategies for chronic hepatitis B infection (CHB). TLR8 activation with ssRNA was shown to enhance follicular helper T cell (T

Indexed as

Antiviral AgentsB-LymphocytesCase-Control StudiesCD40 LigandCells, CulturedEnzyme-Linked Immunospot AssayHepatitis B, ChronicHepatitis B Surface AntigensHepatitis B virusHexanolsHost-Pathogen InteractionsHumansInducible T-Cell Co-Stimulator ProteinInterleukin-21InterleukinsProto-Oncogene Proteins c-bcl-6Antiviral AgentsBCL6 protein, humanCD40 LigandHepatitis B Surface AntigensHexanolsICOS protein, humanInducible T-Cell Co-Stimulator ProteinInterleukin-21InterleukinsProto-Oncogene Proteins c-bcl-6PyrimidinesselgantolimodTLR8 protein, humanToll-Like Receptor 8activation induced marker (AIM)B cellchronic hepatitis Bfollicular helper T cellHBsAg-specific B cell responseinflammatory cytokineselgantolimod (SLGN)toll-like receptor 8

Identifiers

PMID34512670
PMCPMC8428528
OpenAlexW3196619173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.