Evidence map›Paper›PMID 34512619›Full record

ArticleFrontiers in immunology2021

Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From

Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Yoko Nakata, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
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  4. Maintenance of homeostasis by TLR4 ligands.Frontiers in immunology · 2024
    Review
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haruka MizobuchiControl of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
Kazushi YamamotoControl of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
Masashi YamashitaControl of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
Yoko NakataResearch and Development Department Macrophi Inc., Kagawa, Japan.
Hiroyuki InagawaControl of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
Chie KohchiControl of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
Gen-Ichiro SomaControl of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
Niigata University of Pharmacy and Applied Life Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes-related cognitive dysfunction (DRCD) is a serious complication induced by diabetes. However, there are currently no specific remedies for DRCD. Here, we show that streptozotocin-induced DRCD can be prevented without causing side effects through oral administration of lipopolysaccharide (LPS) derived from

Indexed as

Administration, OralAnimalsBrainCells, CulturedCognitive DysfunctionDiabetes ComplicationsDiabetes Mellitus, ExperimentalDisease Models, AnimalLipopolysaccharidesMaleMiceMicrogliaNeuroprotective AgentsPantoeaReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSignal TransductionCsf1r protein, mouseLipopolysaccharidesNeuroprotective AgentsReceptors, Granulocyte-Macrophage Colony-Stimulating Factorcognitive dysfunctiondementialipopolysaccharidemicroglianeuroprotectionoral administration

Identifiers

PMID34512619
PMCPMC8429836
OpenAlexW3196453987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.