Evidence map›Paper›PMID 34512603›Full record

ArticleFrontiers in microbiology2021

Microbial Enzymatic Synthesis of Amikacin Analogs With Antibacterial Activity Against Multidrug-Resistant Pathogens.

Yeon Hee Ban, Myoung Chong Song, Joong Ho Jeong, Min Seok Kwun, Chang Rae Kim, Hwi So Ryu, Eunji Kim, Je Won Park, Dong Gun Lee, Yeo Joon Yoon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Glycodiversification of gentamicins throughActa pharmaceutica Sinica. B · 2024
    Article
  5. Facile and selectiveGreen chemistry : an international journal and green chemistry resource : GC · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yeon Hee BanCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, South Korea.
Myoung Chong SongCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, South Korea.
Joong Ho JeongCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, South Korea.
Min Seok KwunSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, South Korea.
Chang Rae KimDepartment of Integrated Biomedical and Life Sciences, Korea University, Seoul, South Korea.
Hwi So RyuDepartment of Integrated Biomedical and Life Sciences, Korea University, Seoul, South Korea.
Eunji KimCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, South Korea.
Je Won ParkDepartment of Integrated Biomedical and Life Sciences, Korea University, Seoul, South Korea.
Dong Gun LeeSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, South Korea.
Yeo Joon YoonCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, South Korea.
Seoul National University · KRKorea University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the constant emergence of multidrug-resistant gram-negative bacteria, interest in the development of new aminoglycoside (AG) antibiotics for clinical use has increased. The regioselective modification of AG scaffolds could be an efficient approach for the development of new antibiotics with improved therapeutic potency. We enzymatically synthesized three amikacin analogs containing structural modifications in the amino groups and evaluated their antibacterial activity and cytotoxicity. Among them, 6'-

Indexed as

amikacin analogsantibacterial activitycytotoxicitymicrobial enzymatic synthesismultidrug-resistant pathogens

Identifiers

PMID34512603
PMCPMC8430323
OpenAlexW3196730794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.