ReviewFrontiers in endocrinology2021
Sleep, Cognition and Cortisol in Addison's Disease: A Mechanistic Relationship.
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Cognitive Assessment in Adults With Adrenal Cortisol Insufficiency: Challenges and Opportunities.Endocrine reviews · 2026Review
- Efficacy of acupuncture on glucocorticoid-induced insomnia: study protocol for a randomized controlled trial assessed by polysomnographic parameters and 5-HT.Frontiers in neurology · 2026Article
- The Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison's Disease.Clinical endocrinology · 2025Article
- Cold and hot consumption and health outcomes among US Asian and White populations.The British journal of nutrition · 2025Article
- Article
- Review
- Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.Oral diseases · 2025Article
- Dynamic Relationships Among Continuous Glucose Metrics and Momentary Cognitive Performance in Diverse Adults With Type 1 Diabetes.Diabetes care · 2025Article
- Cognitive benefits of sleep: a narrative review to explore the relevance of glucose regulation.Sleep advances : a journal of the Sleep Research Society · 2025Review
- The biological and psychological impact of the Coronavirus disease-19 pandemic on the characteristics of the menstrual cycle.Journal of the Turkish German Gynecological Association · 2024Article
- Translating insights into therapies for Long Covid.Science translational medicine · 2024Review
- Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases.Diseases (Basel, Switzerland) · 2024Review
- Coping with the multifaceted and multifunctional role of cortisol in the brain.Neuroscience applied · 2024Review
- Glucocorticoids and cognitive function: a walkthrough in endogenous and exogenous alterations.Journal of endocrinological investigation · 2023Review
- Interpretation of Steroid Biomarkers in 21-Hydroxylase Deficiency and Their Use in Disease Management.The Journal of clinical endocrinology and metabolism · 2023Review
- Understanding the relationships between physiological and psychosocial stress, cortisol and cognition.Frontiers in endocrinology · 2023Review
- Correlation analysis between sleep quality and the mental health status of female sex workers during the COVID-19 pandemic in Hubei Province.Frontiers in endocrinology · 2023Article
- Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis.Frontiers in endocrinology · 2023Review
- The hidden link between circadian entropy and mental health disorders.Translational psychiatry · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is a critical biological process, essential for cognitive well-being. Neuroscientific literature suggests there are mechanistic relations between sleep disruption and memory deficits, and that varying concentrations of cortisol may play an important role in mediating those relations. Patients with Addison's disease (AD) experience consistent and predictable periods of sub- and supra-physiological cortisol concentrations due to lifelong glucocorticoid replacement therapy, and they frequently report disrupted sleep and impaired memory. These disruptions and impairments may be related to the failure of replacement regimens to restore a normal circadian rhythm of cortisol secretion. Available data provides support for existing theoretical frameworks which postulate that in AD and other neuroendocrine, neurological, or psychiatric disorders, disrupted sleep is an important biological mechanism that underlies, at least partially, the memory impairments that patients frequently report experiencing. Given the literature linking sleep disruption and cognitive impairment in AD, future initiatives should aim to improve patients' cognitive performance (and, indeed, their overall quality of life) by prioritizing and optimizing sleep. This review summarizes the literature on sleep and cognition in AD, and the role that cortisol concentrations play in the relationship between the two.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.