Evidence map›Paper›PMID 34512411›Full record

ArticleFrontiers in psychiatry2021

Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.

Chuanjun Zhuo, Yong Xu, Haibo Wang, Tao Fang, Jiayue Chen, Chunhua Zhou, Qianchen Li, Jie Liu, Shuli Xu, Cong Yao and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

Chuanjun ZhuoKey Laboratory of Multiple Organ Damages of Major Psychoses (MODMP_Lab), Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated With Nankai University, The Fourth Central Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Yong XuDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Haibo WangPeking University Clinical Research Institute, Peking University First Hospital, Beijing, China.
Tao FangKey Laboratory of Multiple Organ Damages of Major Psychoses (MODMP_Lab), Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated With Nankai University, The Fourth Central Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Jiayue ChenKey Laboratory of Real Time Brain Circuit Tracing in Neurology and Psychiatry (RTBNP_Lab), Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated With Nankai University, The Fourth Central Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Chunhua ZhouDepartment of Pharmacology, The First Hospital Affiliated to Hebei Medical University, Shijiazhuang, China.
Qianchen LiDepartment of Pharmacology, The First Hospital Affiliated to Hebei Medical University, Shijiazhuang, China.
Jie LiuLaboratory of Neuro-Imaging and Comorbidity (PNGC_Lab), Tianjin Anding Hospital Affiliated to Nankai University, Tianjin Medical University, Tianjin, China.
Shuli XuLaboratory of Neuro-Imaging and Comorbidity (PNGC_Lab), Tianjin Anding Hospital Affiliated to Nankai University, Tianjin Medical University, Tianjin, China.
Cong YaoLaboratory of Neuro-Imaging and Comorbidity (PNGC_Lab), Tianjin Anding Hospital Affiliated to Nankai University, Tianjin Medical University, Tianjin, China.
Weiliang YangLaboratory of Neuro-Imaging and Comorbidity (PNGC_Lab), Tianjin Anding Hospital Affiliated to Nankai University, Tianjin Medical University, Tianjin, China.
Anqu YangDepartment of Treatment Resistant Schizophrenia, Tianjin Kangtai Hospital, Tianjin, China.
Bo LiDepartment of Treatment Resistant Schizophrenia, Tianjin Kangtai Hospital, Tianjin, China.
Yuhui ChenDepartment of Treatment Resistant Schizophrenia, Tianjin Kangtai Hospital, Tianjin, China.
Hongjun TianKey Laboratory of Multiple Organ Damages of Major Psychoses (MODMP_Lab), Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated With Nankai University, The Fourth Central Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Chongguang LinDepartment of Psychiatry, Wenzhou Seventh Peoples Hospital, Wenzhou, China.
Tianjin Hospital · CNTianjin Fourth Central Hospital · CNTianjin Fourth Hospital · CNTianjin Medical University · CNFirst Affiliated Hospital of Hebei Medical University · CNHangzhou Seventh Peoples Hospital · CNHebei Medical University · CNNankai University · CNPeking University First Hospital · CNShanxi Medical University · CNTianjin Anding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the safety and efficacy of high-dose vitamin B6 (vB6) as an adjunct treatment for antipsychotic-induced hyperprolactinemia (AIHP) in male patients with treatment-resistant schizophrenia (TRS). In this randomized double-blinded controlled study, patients were randomized (1:1) into a control group given aripiprazole (ARI; 10 mg/day;

Indexed as

aripiprazolecognitive abilitydrug repurposingPANSSTRS

Identifiers

PMID34512411
PMCPMC8426548
OpenAlexW3194071753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.