Evidence map›Paper›PMID 34512394›Full record

ArticleFrontiers in physiology2021

Acute Detubulation of Ventricular Myocytes Amplifies the Inhibitory Effect of Cholinergic Agonist on Intracellular Ca

Andriy E Belevych, Vladimir Bogdanov, Dmitry A Terentyev, Sandor Gyorke

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andriy E BelevychDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Vladimir BogdanovDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Dmitry A TerentyevDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Sandor GyorkeDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
The Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

Ryanodine Receptor Channels in Heart FailureR01HL074045 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GYORKE, SANDOR · 2003 to 2024
$8.2M
Novel Mechanisms of Regulation of SK channels: Implications for Cardiac ArrhythmiaR01HL142588 · NHLBI · OHIO STATE UNIVERSITY · PI TERENTYEV, DMITRY A · 2019 to 2022
$2.4M
REgulation of Calcium Homeostasis by MyomiRs in Heart FailureR01HL121796 · NHLBI · RHODE ISLAND HOSPITAL · PI TERENTYEV, DMITRY A · 2015 to 2019
$2.0M
NHLBI NIH HHS R01 HL074045NHLBI NIH HHS R01 HL121796NHLBI NIH HHS R01 HL142588
6 · The paper itself

Abstract

Muscarinic receptors expressed in cardiac myocytes play a critical role in the regulation of heart function by the parasympathetic nervous system. How the structural organization of cardiac myocytes affects the regulation of Ca

Indexed as

calcium microdomainsexcitation-contraction couplingmuscarinic receptor agonistt-tubuleventricular myocyte

Identifiers

PMID34512394
PMCPMC8427700
OpenAlexW3197324083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.