Evidence map›Paper›PMID 34512338›Full record

ArticleFrontiers in pharmacology2021

Wenxin Keli for the Treatment of Arrhythmia-Systems Pharmacology and

Xiaofeng Li, Gang Tian, Liang Xu, Lili Sun, Rui Tao, Shaoqiang Zhang, Zidong Cong, Fangjun Deng, Jinhong Chen, Yang Yu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Xiaofeng LiDepartment of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China.
Gang TianDepartment of Cardiology, Teda International Cardiovascular Hospital, Tianjin, China.
Liang XuSchool of Pharmacy, Tianjin Medical University, Tianjin, China.
Lili SunDepartment of TCM, Tianjin University of TCM, Tianjin, China.
Rui TaoDepartment of TCM, Tianjin University of TCM, Tianjin, China.
Shaoqiang ZhangDepartment of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China.
Zidong CongDepartment of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China.
Fangjun DengDepartment of TCM, Tianjin University of TCM, Tianjin, China.
Jinhong ChenDepartment of TCM, Tianjin University of TCM, Tianjin, China.
Yang YuDepartment of Aeronautics and Astronautics, Tsinghua University, Beijing, China.
Wuxun DuDepartment of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China.
Hucheng ZhaoDepartment of Aeronautics and Astronautics, Tsinghua University, Beijing, China.
Tianjin University · CNTianjin Medical University · CNSecond Hospital of Tianjin Medical University · CNBeihang University · CNTEDA International Cardiovascular Hospital · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study employed a systems pharmacology approach to identify the active compounds and action mechanisms of Wenxin Keli for arrhythmia treatment. Sixty-eight components identified

Indexed as

action mechanismsactive compoundsarrhythmiaCa2+ balancesystems phar macologyWenxin Keli

Identifiers

PMID34512338
PMCPMC8426352
OpenAlexW3195877178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.