Evidence map›Paper›PMID 34512163›Full record

ArticleInternational journal of biological sciences2021

Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.

Yadong Liu, Huiyan Lv, Xingyi Li, Jiannan Liu, Song Chen, Yaodong Chen, Yinshan Jin, Ruihua An, Shiliang Yu, Zhigang Wang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yadong LiuInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Huiyan LvDepartment of Nephrology, The First Affiliated Hospital of Harbin Medical University, No.23 You Zheng Street, Harbin 150001, Heilongjiang, China.
Xingyi LiDepartment of Ultrasonic Imaging, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, China.
Jiannan LiuDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, No.23 You Zheng Street, Harbin 150001, Heilongjiang, China.
Song ChenDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, No.23 You Zheng Street, Harbin 150001, Heilongjiang, China.
Yaodong ChenDepartment of Ultrasonic Imaging, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China.
Yinshan JinDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, No.23 You Zheng Street, Harbin 150001, Heilongjiang, China.
Ruihua AnDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, No.23 You Zheng Street, Harbin 150001, Heilongjiang, China.
Shiliang YuDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, No.23 You Zheng Street, Harbin 150001, Heilongjiang, China.
Zhigang WangInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Harbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNDalian Medical University · CNSecond Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Of all pathological types of renal cell cancer (RCC), clear cell renal cell carcinoma (ccRCC) has the highest incidence. Cyclovirobuxine (CVB), a triterpenoid alkaloid isolated from

Indexed as

AnimalsCarcinoma, Renal CellCell Line, TumorDrugs, Chinese HerbalHumansHuman Umbilical Vein Endothelial CellsInsulin-Like Growth Factor Binding Protein 3Kidney NeoplasmsMAP Kinase Signaling SystemMiceProto-Oncogene Proteins c-aktRandom AllocationSTAT3 Transcription FactorXenograft Model Antitumor Assayscyclovirobuxine DDrugs, Chinese HerbalIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Proto-Oncogene Proteins c-aktSTAT3 protein, humanSTAT3 Transcription FactorAKT/STAT3/MAPKclear cell renal cell carcinoma (ccRCC)CyclovirobuxineEMTIGFBP3Snail

Identifiers

PMID34512163
PMCPMC8416721
OpenAlexW3197634797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.