Evidence map›Paper›PMID 34512162›Full record

ArticleInternational journal of biological sciences2021

miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling.

San-Zhong Li, Kai-Xi Ren, Jing Zhao, Shuang Wu, Juan Li, Jian Zang, Zhou Fei, Jun-Long Zhao

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  14. Comprehensive analysis of PDE2A: a novel biomarker for prognostic value and immunotherapeutic potential in human cancers.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
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  16. [miRNA-128-3p inhibits malignant behavior of glioma cells by downregulating KLHDC8A expression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

San-Zhong LiDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Kai-Xi RenDepartment of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710032, China.
Jing ZhaoDepartment of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Shuang WuDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Juan LiDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Jian ZangState Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an 710032, China.
Zhou FeiDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Jun-Long ZhaoState Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an 710032, China.
Air Force Medical University · CNXijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Neoplastic Stem CellsWnt Signaling PathwayAnimalsbeta CateninCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 2GliomaHumansMiceMice, NudeMicroRNAsReceptor, Notch1beta CateninCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 2MicroRNAsMIRN139 microRNA, humanPDE2A protein, humanReceptor, Notch1glioma stem cellmiR-139Notch1PDE2AWnt/β-catenin

Identifiers

PMID34512162
PMCPMC8416740
OpenAlexW3197368904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.