Evidence map›Paper›PMID 34511911›Full record

ReviewInternational journal of nanomedicine2021

Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment.

Wenli Zhang, Enshi Hu, Yajie Wang, Si Miao, Yanyan Liu, Yumin Hu, Ji Liu, Bohui Xu, Daquan Chen, Yan Shen

Open access · goldAbstract readReview
In one paragraph

Review in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 50 citations in OpenAlex.

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  17. Selected strategies to fight pathogenic bacteria.Journal of enzyme inhibition and medicinal chemistry · 2023
    Review
  18. Advances in Nanostructures for Antimicrobial Therapy.Materials (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wenli Zhang *Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Enshi Hu *Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Yajie Wang *Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Si MiaoDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Yanyan LiuDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Yumin HuDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Ji LiuDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Bohui XuSchool of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China.ORCID 0000-0002-2551-6420
Daquan ChenSchool of Pharmacy, Yantai University, State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, 264005, People's Republic of China.ORCID 0000-0002-6796-0204
Yan ShenDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.ORCID 0000-0002-9586-7373
China Pharmaceutical University · CNNantong University · CNYantai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.

Indexed as

Anti-Infective AgentsBacterial InfectionsAnti-Bacterial AgentsDrug Delivery SystemsDrug Resistance, BacterialHumansAnti-Bacterial AgentsAnti-Infective Agentsantimicrobialdrug deliverynanocarrierstargeting strategies

Identifiers

PMID34511911
PMCPMC8423451
OpenAlexW3197227545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.