ArticleInternational journal of chronic obstructive pulmonary disease
Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD.
Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Symptom Clusters of Chronic Obstructive Pulmonary Disease and Their Correlation With Health-Related Quality of Life: A Systematic Review.Nursing open · 2026Pooled it
- Association between impairment of lung function and risk of anxiety and depression in patients with chronic obstructive pulmonary disease-a systematic review.Systematic reviews · 2024Pooled it
- Differences in systemic inflammation and prethrombotic biomarkers between AECOPD patients with and without pulmonary hypertension.Journal of inflammation (London, England) · 2026Article
- Review
- Immune-inflammatory profiles are associated with exercise capacity and psychological status in hospitalized patients with acute exacerbation of COPD.Scientific reports · 2026Article
- Integrated Pulmonary Severity Score (IPSS) for COPD: A Psycho-Respiratory Risk Index Supported by Explainable Machine Learning.Diagnostics (Basel, Switzerland) · 2026Article
- Association between the C-reactive protein-albumin-lymphocyte index and incident depression in patients with chronic obstructive pulmonary disease: a prospective cohort study from the UK biobank.Frontiers in medicine · 2026Article
- Disability in Older Adults with COPD: Prevalence, Assessment, and Influencing Factors - A Scoping Review.Clinical interventions in aging · 2026Article
- Heart rate variability associated with depression and lung decline in chronic obstructive pulmonary disease: Mechanisms and interventions.World journal of psychiatry · 2025Article
- Depression and Anxiety as Comorbidities in Chronic Obstructive Pulmonary Disease: A Comprehensive Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Anxiety and Depression in Mild and Moderate COPD Patients: An Observational, Cross-Sectional Study in Greece.Diseases (Basel, Switzerland) · 2025Article
- Mesenchymal stem cell-derived exosomes-a promising therapeutic approach to improve neurocognitive disorders in chronic obstructive pulmonary disease.Stem cell research & therapy · 2025Review
- The combined impact of neutrophil-percentage-to-albumin ratio and depressive symptoms on mortality in US arthritis patients: insights from NHANES (2005-2018).Frontiers in public health · 2025Article
- Correlation between serum inflammatory factors and psychosomatic syndrome in patients with chronic obstructive pulmonary disease: an observational study.Frontiers in psychiatry · 2025Article
- Immune imbalance underlying depressive symptoms in COPD patients: a study based on BDNF, PD-1, MMP-9, and inflammatory cytokines.Frontiers in medicine · 2025Article
- Assessment of Metabolic Syndrome in Patients with Chronic Obstructive Pulmonary Disease: A 6-Month Follow-Up Study.Diagnostics (Basel, Switzerland) · 2024Article
- Identification of factors directly linked to incident chronic obstructive pulmonary disease: A causal graph modeling study.PLoS medicine · 2024Article
- Apocynin Prevents Cigarette Smoke-Induced Anxiety-Like Behavior and Preserves Microglial Profiles in Male Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Inflammation mechanism and research progress of COPD.Frontiers in immunology · 2024Review
- Omega-3 Polyunsaturated Fatty Acids in Managing Comorbid Mood Disorders in Chronic Obstructive Pulmonary Disease (COPD): A Review.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleDepression is a prevalent comorbidity of chronic obstructive pulmonary disease (COPD) that, along with COPD, has been associated with inflammation. An association between inflammation and depression in COPD has not been validated in a large COPD cohort.
methodsIndividuals from the University of Pittsburgh SCCOR cohort and the COPDGene cohort with tobacco use history and airway obstruction (FEV
resultsThe SCCOR cohort included 220 obstructed participants: 44% female and 21.4% with elevated depressive symptoms. GOLD staging distribution was predominantly stage I and II. The COPDGene cohort included 745 obstructed participants: 44% female and 13.0% with elevated depressive symptoms. GOLD distribution was predominantly stage II and III. In the SCCOR cohort, correlation between IL-6 and depressive symptoms trended toward significance (p= 0.08). Multivariable modeling adjusted for FEV
conclusionElevated plasma IL-6 levels are associated with depressive symptoms in individuals with COPD independent of airflow limitation and comorbid risk factors for depression. Our results suggest that systemic inflammation may play a significant and possibly bidirectional role in depression associated with COPD.
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Registered trials
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