Evidence map›Paper›PMID 34511893›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters.

Richard Kraemer, Hans-Jürgen Smith, Fabian Gardin, Jürg Barandun, Stefan Minder, Lukas Kern, Martin H Brutsche

Abstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Richard KraemerCenter of Pulmonary Medicine, Hirslanden Private Hospital Group, Salem-Hospital, Bern, Switzerland.
Hans-Jürgen SmithMedical Development, Research in Respiratory Diagnostics, Berlin, Germany.
Fabian GardinCenter of Pulmonary Medicine, Hirslanden Private Hospital Group, Clinic Hirslanden, Zürich, Switzerland.
Jürg BarandunCenter of Pulmonary Medicine, Hirslanden Private Hospital Group, Clinic Hirslanden, Zürich, Switzerland.
Stefan MinderMedical Development, Research in Respiratory Diagnostics, Berlin, Germany.
Lukas KernClinic of Pneumology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Martin H BrutscheClinic of Pneumology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.ORCID 0000-0002-1612-3609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAirflow reversibility criteria in COPD are still debated - especially in situations of co-existing COPD and asthma. Bronchodilator response (BDR) is usually assessed by spirometric parameters. Changes assessed by plethysmographic parameters such as the effective, specific airway conductance (sG

methodsFrom databases of 3 pulmonary centers, BDR to 200 g salbutamol was retrospectively evaluated by spirometric (∆FEV

resultsEvaluating z-score improvement taking into consideration the whole pre-test z-score range, highest BDR was achieved by combining ∆sG

conclusionBDR largely depends on the pre-test functional severity and, therefore, should be evaluated in relation to the pre-test conditions expressed as ∆z-scores, considering changes in airway dynamics, changes in static lung volumes and changes in small airway function. Plethysmographic parameters demonstrated BDR at a significant higher rate than spirometric parameters.

Indexed as

AsthmaPulmonary Disease, Chronic ObstructiveBronchodilator AgentsForced Expiratory VolumeHumansRetrospective StudiesSpirometryBronchodilator AgentsACOaerodynamic work of breathingbronchodilator responseCOPDCOPD and coexisting asthmapulmonary hyperinflationsmall airways dysfunction

Identifiers

PMID34511893
PMCPMC8420556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.