Evidence map›Paper›PMID 34511824›Full record

ArticleJournal of clinical and experimental hepatology

If Hoofbeats are not From Horses, It Could be Zebras!! Isolated Hyper-alkaline Phosphatasemia.

Mahak Chauhan, David H Alpers, James P Hamilton, Paul J Thuluvath

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Mahak ChauhanInstitute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, USA.
David H AlpersDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
James P HamiltonDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Paul J ThuluvathInstitute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, USA.
Johns Hopkins University · USMercy Medical Center · USUniversity of Maryland, Baltimore · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alkaline phosphatase (AP) is a membrane bound enzyme and when it is elevated in blood, it is mostly due to either hepatobiliary or bone diseases. We report isolated intestinal hyperphosphatasemia (IAP) in two sisters. Both sisters presented with identical trends of isolated AP elevation. Both underwent extensive workup for liver diseases including cholangiograms, and none was identified. Subsequent isoenzyme electrophoresis showed that 45%-56% of the elevated AP was due to IAP. This elevation of the intestinal AP is consistent with a rare hereditary biochemical abnormality, benign familial intestinal hyperphosphatemia. This condition should be considered in the differential diagnosis of otherwise isolated serum AP levels to avoid unnecessary investigations.

Indexed as

alkaline phosphatase isozymeBFIH, Benign familial intestinal hyperphosphatasemiaCKDs, Chronic kidney diseasesDILI, Drug-induced liver injuryelevated alkaline phosphataseERCP, Endoscopic retrograde cholangiopancreatographyfamilial benign intestinal alkaline hyperphosphatasemiahyperphosphatasemiaIAP, Intestinal alkaline hyperphosphatasemiaMRCP, Magnetic resonance cholangiopancreatographyPSC, Primary sclerosing cholangitisTNAP, Tissue non-specific AP

Identifiers

PMID34511824
PMCPMC8414313
OpenAlexW3112993515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.