Evidence map›Paper›PMID 34511819›Full record

ArticleJournal of clinical and experimental hepatology

A Long-Term Prospective Study of Quality of Life, Abdominal Symptoms, and Cosmesis of Donors After Hepatectomy for Live-Donor Liver Transplantation.

Piyush K Sinha, Nihar Mohapatra, Kishore Gs Bharathy, Guresh Kumar, Viniyendra Pamecha

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05186116 (Living Donor Liver Transplantation), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05186116 narecruitingnot on this map

Living Donor Liver Transplantation (LDLT) in Non Resectable Colo-rectal Cancer Liver Metastasis. The LIVERMORE Trial (LIVing Donor livEr tRansplant Modena cOloRectal mEtastasis) [Original Title in Italian: "Trapianto di Fegato da Donatore Vivente Per Metastasi Epatiche Non Resecabili da Adenocarcinoma Del Colon"]

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria di ModenaRan2022 to 2032Enrolled25ConditionsColon Adenocarcinoma, Liver Metastasis Colon CancerArmsLiving donor liver transplant, Split liver transplant, RAPID, DDLT
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Piyush K SinhaDepartment of Hepato Pancreato Biliary and Liver Transplant Surgery, Institute of Liver & Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
Nihar MohapatraDepartment of Hepato Pancreato Biliary and Liver Transplant Surgery, Institute of Liver & Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
Kishore Gs BharathyDepartment of Hepato Pancreato Biliary and Liver Transplant Surgery, Institute of Liver & Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
Guresh KumarDepartment of Biostatistics, Institute of Liver & Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
Viniyendra PamechaDepartment of Hepato Pancreato Biliary and Liver Transplant Surgery, Institute of Liver & Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
Institute of Liver and Biliary Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComprehensive assessment of quality of life of live liver donors is required for adequate donor outcome reporting, but there is a lack of prospective data. Assessment of all aspects of liver donation over a long period is a necessity to have complete understanding of the donation process.

methodsProspectively collected data of liver donors operated between March 2012 to August 2013, examined donors (n = 52) from predonation to five years after the donation. Participants were administered 'World Health Organization quality of life Brief and questionnaires' regarding their attitude predonation, their overall well-being in terms of abdominal symptoms, cosmesis, and satisfaction with donation and consent process at predefined time points till five years after donation. The weight of the donors was recorded at predefined time points.

resultsThe donors whose recipients died were less likely to continue with the study (8.9% vs. 71.4%; P < 0.001). After surgery, physical domain took 2 years to reach to predonation level while psychological and social relationship domains took 3 months and 1 month, respectively; environmental domain remained stable throughout. Even after recovery and discharge from hospital, donors experienced abdominal symptoms for a long period of time, but as the time increased from donation the reporting of symptoms decreased. Body image scores (12 ± 2.46 at 3 months vs. 14.9 ± 3.16 at five years, P < 0.001) and cosmesis scores (14.6 ± 3.67 at 3 months vs. 18.75 ± 3 at five years, P < 0.001) significantly improved over time. There was significant weight gain in donors (65.2 ± 6.1 kg predonation vs. 70.69 ± 2.4 kg at 2 years P < 0.001). Donors understood the consent process well, but did not use it for decision making. Overall, they showed a high level of satisfaction in the donation process.

conclusionDonors have good quality of life and show steady recovery in all aspects. Recipient death affects attitude towards donation process.

Indexed as

donor cosmesisGERD, gastroesophageal reflux diseaseHRQOL, health-related quality of lifeLDLT, live-donor liver transplantationliver donor quality of lifeliving-donor liver transplantationliving liver donor symptomsLLDs, live liver donorsSF 36, Short Form 36WHOQOL-BREF, World Health Organization quality of life Brief

Identifiers

PMID34511819
PMCPMC8414308
OpenAlexW3112025039

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.