Evidence map›Paper›PMID 34511814›Full record

ArticleJournal of clinical and experimental hepatology

Nonalcoholic Fatty Liver in Lean Individuals: Clinicobiochemical Correlates of Histopathology in 157 Liver Biopsies from Healthy Liver Donors.

Narendra S Choudhary, Neeraj Saraf, Sanjiv Saigal, Ajay Duseja, Dheeraj Gautam, Amit Rastogi, Prashant Bhangui, Srinivasan Thiagrajan, Arvinder S Soin

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Role of ChREBP-PPARα-FGF21 Axis in Metabolic Dysfunction of MASLD.International journal of molecular sciences · 2025
    Article
  2. Article
  3. NAFLD in normal weight individuals.Diabetology & metabolic syndrome · 2022
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Liver Stiffness Values in Persons with Normal Histology.Journal of clinical and experimental hepatology
    Article
  12. Lean Fatty Liver Disease: Through Thick and Thin.Journal of clinical and experimental hepatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Narendra S ChoudharyMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Neeraj SarafMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Sanjiv SaigalMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Ajay DusejaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Dheeraj GautamDepartment of Histopathology, Medanta, the Medicity, Gurgaon, India.
Amit RastogiMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Prashant BhanguiMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Srinivasan ThiagrajanMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Arvinder S SoinMedanta Institute of Liver Transplantation and Regenerative Medicine, Medanta, the Medicity, Gurgaon, India.
Medanta The Medicity · INPost Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenerally diagnosis of non-alcoholic fatty disease is made on imaging, however, mild steatosis is difficult to diagnose on imaging. Liver biopsy is the procedure of choice but is not carried out as it is an invasive procedure. We describe our experience of 157 liver biopsies in living liver donors with normal body mass index (BMI) <23 kg/M MATERIALS AND

methodsThe study was conducted at a tertiary care center in north India. Data of lean living donors who underwent a liver biopsy before donation were analyzed. Data are presented as percentage, mean, or median (25-75 interquartile range).

resultsOf 718 donors who had a liver biopsy before donation, 157 (21.8%) donors were lean (BMI < 23 kg/M

conclusionOne third of lean donors had NAFL. Among all metabolic risk factors, only higher TGs levels showed a significant association with NAFL.

Indexed as

ALP, alkaline phosphataseALT, alanine transaminaseAST, aspartate transaminasebiopsyBMI, body mass indexCT, computed tomographyGGT, gamma glutamyl transpeptidaseGRWR, graft-to-recipient weight ratioHDL, high-density lipoproteinIR, insulin resistanceLAI, liver attenuation indexmetabolic syndromeMR, magnetic resonanceNAFLD, nonalcoholic fatty liver diseaseNAFL, nonalcoholic fatty liverPNPLA3, patatin-like phospholipase domain-containing protein 3TG, triglyceridetriglyceridesUSG, ultrasound

Identifiers

PMID34511814
PMCPMC8414316
OpenAlexW3128118716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.