Evidence map›Paper›PMID 34511792›Full record

ArticleIndian journal of palliative care

Modulation of the Extracellular Signal-Regulated Protein Kinase and Tissue Inhibitors of Matrix Metalloproteases-1 Gene in Chronic Neuropathic Pain.

Ashok Kumar Saxena, Deepanshu Khrolia, Geetanjali T Chilkoti, Prakash Gyandev Gondode, Tusha Sharma, Gaurav Thakur, Basu Dev Banerjee

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In one paragraph

Article in Indian journal of palliative care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ashok Kumar SaxenaDepartment of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Maharashtra, India.
Deepanshu KhroliaDepartment of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Maharashtra, India.
Geetanjali T ChilkotiDepartment of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Maharashtra, India.
Prakash Gyandev GondodeDepartment of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Tusha SharmaDepartment of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
Gaurav ThakurDepartment of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
Basu Dev BanerjeeDepartment of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
University College of Medical Sciences · INAll India Institute of Medical Sciences, NagpurGuru Teg Bahadur Hospital · INUniversity of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to study the modulation of extracellular signal-regulated protein kinase (ERK) and tissue inhibitors of matrix metalloproteases 1 (TIMP 1) gene in patients with neuropathic pain (NP). MATERIALS AND

methodsIn the present, cross-sectional, observational study, 2 ml of venous baseline sample was withdrawn from all the patients with neuropathic (NP) or non NP (NNP) soon after their diagnosis or on their first visit to the pain clinic. A real-time quantitative polymerase chain reaction experiment was conducted to measure the mRNA expression of TIMP1 and ERK genes in blood samples. The Delta Ct, Delta Ct, and fold change analysis of both the genes were conducted between patients with NP and NNP.

resultsA total of 285 patients with chronic pain were assessed, out of which, 153 patients had NP and 132 had NNP. The average duration of chronic pain was 11 months for 285 patients. The mRNA expression of TIMP1 gene is significantly down regulated (2.65-fold) (

conclusionThe mRNA expression of TIMP1 gene is significantly down regulated, and ERK is significantly up regulated in patients with NP. Further, multicentric trials with larger sample size are recommended to confirm this finding.

Indexed as

Chronic neuropathic painExtracellular signal-regulated protein kinaseTissue inhibitors of matrix metalloproteases 1

Identifiers

PMID34511792
PMCPMC8428873
OpenAlexW3194655900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.