Evidence map›Paper›PMID 34511573›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript.

Naoki Miyashita, Masahiro Onozawa, Keito Suto, Shinichi Fujisawa, Nanase Okazaki, Daisuke Hidaka, Hiroyuki Ohigashi, Atsushi Yasumoto, Junichi Sugita, Daigo Hashimoto and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. The silent players: AtypicalOncology reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Naoki MiyashitaDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Masahiro OnozawaDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Keito SutoDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Shinichi FujisawaDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Japan.
Nanase OkazakiDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Daisuke HidakaDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Hiroyuki OhigashiDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Atsushi YasumotoDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Junichi SugitaDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Daigo HashimotoDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Yoshihiro MatsunoDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Takanori TeshimaDepartment of Hematology, Faculty of Medicine, Hokkaido University, Japan.
Hokkaido University · JPHokkaido University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Right neck swelling and pain occurred in a 49-year-old man. A Blood count showed a slight increase in platelet count without leukemoid reaction. After a biopsy of the cervical mass and bone marrow aspiration, a diagnosis of extramedullary blast crisis (EBC) of chronic myeloid leukemia (CML) was made. Fluorescence in situ hybridization (FISH) analysis showed a BCR-ABL1 fusion signal, but results of real-time polymerase chain reaction (RT-PCR) for major and minor BCR-ABL1 transcripts were negative. We identified a rare e1a3 BCR-ABL1 fusion transcript. Administration of dasatinib resulted in disappearance of the extramedullary tumor. This is the first reported case of CML-EBC with e1a3 transcript. An aleukemic extramedullary tumor can be the initial presentation of CML.

Indexed as

Blast CrisisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveDasatinibFusion Proteins, bcr-ablHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedDasatinibFusion Proteins, bcr-ablBCR-ABL1e1a3extramedullary blast crisisPhiladelphia (Ph) chromosome

Identifiers

PMID34511573
PMCPMC9038454
OpenAlexW3200081702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.