Evidence map›Paper›PMID 34511567›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Repeated Necrotizing Lymphadenitis with MEFV Gene Mutations.

Yuta Yamamura, Kengo Furuichi, Tadashi Toyama, Megumi Oshima, Hisayuki Ogura, Koichi Sato, Shiori Nakagawa, Taro Miyagawa, Shinji Kitajima, Akinori Hara and 8 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Yuta YamamuraDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Kengo FuruichiDepartment of Nephrology, School of Medicine, Kanazawa Medical University, Japan.
Tadashi ToyamaDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Megumi OshimaDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Hisayuki OguraDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Koichi SatoDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Shiori NakagawaDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Taro MiyagawaDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Shinji KitajimaDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Akinori HaraDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Yasunori IwataDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Norihiko SakaiDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Miho ShimizuDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Hiroko IkedaDepartment of Diagnostic Pathology, Kanazawa University Hospital, Japan.
Tomoko TomaDepartment of Pediatrics, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Kazuya TakasawaDepartment of Internal Medicine, Public Central Hospital of Matto Ishikawa, Japan.
Akihiro YachieDivision of Medical Safety, Kanazawa University, Japan.
Takashi WadaDepartment of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Kanazawa University · JPKanazawa Medical University · JPKanazawa University Hospital · JPPublic Central Hospital of Matto Ishikawa · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a 36-year-old man with repeated necrotizing lymphadenitis due to MEFV gene mutations. The patient's chief complaints were a fever and painful cervical lymphadenopathy. We diagnosed him with necrotizing lymphadenitis based on the pathological findings of the lymph nodes and the exclusion of other differential diseases. The same episode recurred four times. We speculated the involvement of autoinflammatory backgrounds and detected MEFV gene mutations of E148Q (homo), P369S, and R408Q. Considering the elevation of interleukin-18, these mutations probably played roles in the repeated necrotizing lymphadenitis.

Indexed as

LymphadenitisAdultFeverHumansLymph NodesMaleMutationPainPyrinMEFV protein, humanPyrinautoinflammatory diseaseinflammasomeMEFV gene mutationnecrotizing lymphadenitis

Identifiers

PMID34511567
PMCPMC9038464
OpenAlexW3200932042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.