Evidence map›Paper›PMID 34511483›Full record

ArticleCancer biomarkers : section A of Disease markers2022

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection.

Al Flores-Bustamante, Laura Hernández-Regino, Manuel-De-Jesús Castillejos-López, Daniel Martínez-Rodríguez, Arnoldo Aquino-Gálvez, Marta Zapata-Tarrés, Armando de Uña-Flores, Citlaltepetl Salinas-Lara, Patricia Sierra-Vargas, Luz María Torres-Espíndola

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In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Al Flores-BustamantePharmacology Laboratory, National Institute of Pediatrics, Mexico City, Mexico.
Laura Hernández-ReginoPharmacology Laboratory, National Institute of Pediatrics, Mexico City, Mexico.
Manuel-De-Jesús Castillejos-LópezHospital Epidemiology and Infectology Unit, National Institute of Respiratory Diseases, Mexico City, Mexico.
Daniel Martínez-RodríguezPharmacology Laboratory, National Institute of Pediatrics, Mexico City, Mexico.
Arnoldo Aquino-GálvezBiomedical Oncology Laboratory, National Institute of Respiratory Diseases, Mexico City, Mexico.
Marta Zapata-TarrésOncology Service, National Institute of Paediatrics, Mexico City, Mexico.
Armando de Uña-FloresRadiology and Imaging Service, National Institute of Paediatrics, Mexico City, Mexico.
Citlaltepetl Salinas-LaraPathology Department, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Patricia Sierra-VargasBiochemist Research and Environmental Medicine Laboratory, National Institute of Respiratory Diseases "Ismael Cosio Villegas", Mexico City, Mexico.
Luz María Torres-EspíndolaPharmacology Laboratory, National Institute of Pediatrics, Mexico City, Mexico.
Instituto Nacional de Neurología y Neurocirugía · MXNational Institute of Cardiovascular Diseases · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChanges in neutrophil to lymphocyte ratio (ΔNLR) have been used as a clinical tool for stratification and prognosis of patients with solid tumors, there is scarce evidence of their clinical relevance in patients with tumors of the central nervous system who have also undergone surgical resection.

objectiveDetermine if (ΔNLR) are associated with poor response to treatment and worse prognosis in pediatric patients with central nervous system tumors (CNST) who underwent surgical resection.

methodsWe performed a retrospective cohort study; demographic, clinical, and hematological variables were evaluated, Kaplan-Meier survival curves and Cox proportional hazards regression model were performed to evaluate prognosis.

resultsThe ΔNLR cutoff value obtained through the third interquartile range was 4.30; The probability of survival and complete response to treatment was different between patients with high ΔNLR when compared to patients with low ΔNLR (p= 0.013, p=≪ 0.001, respectively). A high ΔNLR behaved as an independent predictor of worse Overall Survival (HR 2,297; 95% CI: 1,075-4.908, p= 0.032).

conclusionAn elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.

Indexed as

Central Nervous System NeoplasmsNeutrophilsChildHumansKaplan-Meier EstimateLymphocytesPrognosisRetrospective StudiesCentral nervous system tumorsneutrophil-to-lymphocyte ratiopediatricprognostic factorsurvivaltumor resection

Identifiers

PMID34511483
PMCPMC12364160
OpenAlexW3201241299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.