ArticleLipids in health and disease2021
Low density lipoprotein cholesterol and all-cause mortality rate: findings from a study on Japanese community-dwelling persons.
Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- Predictive value of high-density lipoprotein cholesterol and the cardio-ankle vascular index on cardiovascular outcomes in subjects with cardiovascular risks: the COUPLING Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association Between the Creatinine-to-Body Weight Ratio and All-Cause Mortality in a Rural Japanese Community.Cureus · 2025Article
- Integrative biomarker analysis in diabetic foot: lipids, cellular integrity, and hydration balance.Diabetology & metabolic syndrome · 2025Article
- Unravelling the association of glycosylated haemoglobin A1c, blood pressure, and LDL-cholesterol (ABC) with all-cause mortality in Type 2 diabetes patients: insights from a middle-income country.Journal of diabetes and metabolic disorders · 2025Article
- Is Targeting LDL-C Levels Below 70 mg/dL Beneficial for Cardiovascular and Overall Health? A Critical Examination of the Evidence.Journal of clinical medicine · 2025Review
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- Systemic immune inflammation index and all-cause mortality in chronic kidney disease: A prospective cohort study.Immunity, inflammation and disease · 2024Article
- Can Serum Gamma-Glutamyl Transferase Predict All-Cause Mortality in Hypertensive Patients?Cureus · 2024Article
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- A non-linear association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality among patients with hypertension.Frontiers in cardiovascular medicine · 2024Article
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- Optimal LDL cholesterol levels in young and old patients with type 2 diabetes for secondary prevention of cardiovascular diseases are different.Endocrine connections · 2023Article
- Plant-Based Nutrition: Exploring Health Benefits for Atherosclerosis, Chronic Diseases, and Metabolic Syndrome-A Comprehensive Review.Nutrients · 2023Review
- Serum uric acid to creatinine ratio is a useful predictor of all-cause mortality among hypertensive patients.Clinical hypertension · 2023Article
- Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons.International journal of analytical chemistry · 2023Article
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- Hyperuricemia is associated with all-cause mortality among males and females: Findings from a study on Japanese community-dwelling individuals.Metabolism open · 2022Article
- Association between alanine aminotransferase and all-cause mortality rate: Findings from a study on Japanese community-dwelling individuals.Journal of clinical laboratory analysis · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-density lipoprotein cholesterol (LDL-C) independently impacts aging-related health outcomes and plays a critical role in cardiovascular diseases (CVDs). However, there are limited predictive data on all-cause mortality, especially for the Japanese community population. In this study, it was examined whether LDL-C is related to survival prognosis based on 7 or 10 years of follow-up.
methodsParticipants included 1610 men (63 ± 14 years old) and 2074 women (65 ± 12 years old) who participated in the Nomura cohort study conducted in 2002 (first cohort) and 2014 (second cohort) and who continued throughout the follow-up periods (follow-up rates: 94.8 and 98.0%). Adjusted relative risk estimates were obtained for all-cause mortality using a basic resident register. The data were analyzed by a Cox regression with the time variable defined as the length between the age at the time of recruitment and that at the end of the study (the age of death or censoring), and risk factors including gender, age, body mass index (BMI), presence of diabetes, lipid levels, renal function, serum uric acid levels, blood pressure, and history of smoking, drinking, and CVD.
resultsOf the 3684 participants, 326 (8.8%) were confirmed to be deceased. Of these, 180 were men (11.2% of all men) and 146 were women (7.0% of all women). Lower LDL-C levels, gender (male), older age, BMI under 18.5 kg/m
conclusionsThere is an inverse relationship between LDL-C levels and the risk of all-cause mortality, and this association is statistically significant.
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