ArticleBMC musculoskeletal disorders2021
The risk factors of polymicrobial periprosthetic joint infection: a single-center retrospective cohort study.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Corynebacterium periprosthetic joint infection: a systematic review of 52 cases at 2.5 years follow-up.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip.Antimicrobial agents and chemotherapy · 2024Trial
- Increased Polymicrobial Infection Rates and Associated Mortality in Patients With Chronic Gastrointestinal Disease Undergoing Antibiotic Spacer Placement for Periprosthetic Joint Infection.Arthroplasty today · 2026Article
- Debridement, Antibiotics and Implant Retention in the Management of Periprosthetic Joint Infection: One-Year Outcomes, Epidemiology and Predictors of Failure.Journal of clinical medicine · 2026Article
- One-stage exchange arthroplasty for periprosthetic joint infection following total knee arthroplasty with sinus tract: a mid-to short-term follow-up study.BMC musculoskeletal disorders · 2026Article
- What constitutes a true polymicrobial periprosthetic joint infection? From multiple detections to organism-level causality.Frontiers in microbiology · 2026Review
- Advancing diagnostics in suspected periprosthetic joint infections using synthetic synovial fluid and microcalorimetry.Journal of bone and joint infection · 2026Article
- Risk factors predicting the reinfection in periprosthetic joint infection with sinus tracts following prosthesis removal and antibiotic bone cement spacer implantation: a case control study.BMC infectious diseases · 2025Article
- Polymicrobial Prosthetic Joint Infections: Unraveling Risk Factors and Outcomes in a Single-Center Study.Microorganisms · 2025Article
- Prolonged incubation time unwarranted for acute periprosthetic joint infections.Journal of clinical microbiology · 2025Article
- The Role of Applying Metagenomic Next-Generation Sequencing (mNGS) in Periprosthetic Joint Infection with Sinus Tract: A Retrospective Study.International journal of general medicine · 2025Article
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- What are the risk factors and microorganism profiles of periprosthetic hip joint infections with a concomitant sinus tract?Archives of orthopaedic and trauma surgery · 2024Article
- Poor Outcomes of Girdlestone Resection Arthroplasty in Injection Drug Users: A Retrospective Study.Antibiotics (Basel, Switzerland) · 2024Article
- Rising challenges in periprosthetic joint infections: a focus on rare pathogens and their clinical implications.Frontiers in cellular and infection microbiology · 2024Article
- Serratia marcescens prosthetic joint infection: two case reports and a review of the literature.Journal of medical case reports · 2023Review
- Is a preoperative pathogen detection a prerequisite before undergoing one-stage exchange for prosthetic joint infection of the hip?Archives of orthopaedic and trauma surgery · 2023Article
- Cultures in periprosthetic joint infections, the imperfect gold standard?EFORT open reviews · 2023Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriprosthetic joint infection is a serious complication after total joint arthroplasty and polymicrobial PJI which compose a subtype of PJI often indicate worse outcomes compared to monomicrobial periprosthetic joint infection. However, a literature review suggested that there were limited number studies evaluating the risk factors of polymicrobial PJI. MATERIALS AND
methodsBetween 2015 January and 2019 December, a total of 64 polymicrobial PJI patients and 158 monomicrobial PJI patients in a tertiary center were included in this study and corresponding medical records were scrutinized. The diagnosis of PJI was based on 2014 MSIS criteria. Logistic regression was used to identify the association between various variables and polymicrobial PJI and ROC curve was used to identify their efficiency.
resultsThe prevalence of polymicrobial PJI is 28.3% in our cohorts. After adjusting for the presence of sinus, previous and knee infection, isolation of enterococci (OR, 3.025; 95%CI (1.277,7.164) p = 0.012), infection with atypical organisms (OR, 5.032;95%CI: (1.470,17.229) p = 0.01), infection with gram-negative organisms (OR, 2.255; 95%CI (1.011,5.031) p = 0.047), isolation of streptococcus spp. (OR, 6; 95%CI (2.094,17.194) p = 0.001), and infection with CNS (OfR, 2.183;95%CI (1.148,4.152) p = 0.017) were risk factors of polymicrobial PJI compared to monomicrobial PJI. However, knee infection is related to a decreased risk of polymicrobial PJI with an adjusted OR = 0.479 (p = 0.023).
conclusionThis study demonstrated that the prevalence of polymicrobial PJI is 28.3% in PJI patients. Moreover, the presence of sinus tract and previous joint revisions were risk factors for identifying different bacterial species in the intraoperative specimens. Therefore, in these PJI cases, it is necessary to examine multiple specimens of both intraoperative tissue and synovial fluid for increasing the detection rate and obtaining resistance information.
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