Evidence map›Paper›PMID 34510894›Full record

ArticleBiochemistry2021

Characterization of a Copper-Chelating Natural Product from the Methanotroph

Yun Ji Park, Gerri M Roberts, Rana Montaser, Grace E Kenney, Paul M Thomas, Neil L Kelleher, Amy C Rosenzweig

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yun Ji ParkDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Gerri M RobertsDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Rana MontaserDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-5811-4137
Grace E KenneyDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Paul M ThomasDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Neil L KelleherDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-8815-3372
Amy C RosenzweigDepartments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-8472-4134
Northwestern University · US

Funding

TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
Metalloenzymes and metal homeostasisR35GM118035 · NIGMS · NORTHWESTERN UNIVERSITY · PI AMY C. ROSENZWEIG · 2016 to 2026
$7.1M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
600 MHz NMR Instrument Upgrade at Northwestern UniversityS10OD012016 · OD · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2012 to 2012
$267k
Characterization of new methanobactins and their biosynthetic enzymesF32GM131665 · NIGMS · NORTHWESTERN UNIVERSITY · PI PARK, YUN JI · 2019 to 2020
$158k
NCRR NIH HHS S10 RR019071NIGMS NIH HHS F32 GM131665NIGMS NIH HHS P41 GM108569NIGMS NIH HHS R35 GM118035NIH HHS S10 OD012016NIH HHS S10 OD025194
6 · The paper itself

Abstract

Methanobactins (Mbns) are ribosomally produced, post-translationally modified peptidic natural products that bind copper with high affinity. Methanotrophic bacteria use Mbns to acquire copper needed for enzymatic methane oxidation. Despite the presence of Mbn operons in a range of methanotroph and other bacterial genomes, few Mbns have been isolated and structurally characterized. Here we report the isolation of a novel Mbn from the methanotroph

Indexed as

Amino Acid SequenceBacterial ProteinsBiological ProductsChelating AgentsCopperGene ExpressionGene Expression Regulation, BacterialGenome, BacterialImidazolesMethaneMethylosinusMethylosinus trichosporiumOligopeptidesOperonOxidation-ReductionPeptidesBacterial ProteinsBiological ProductsChelating AgentsCopperImidazolesMethanemethanobactinOligopeptidesPeptides

Identifiers

PMID34510894
PMCPMC8739258
OpenAlexW3201617023

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.